biostudies-literatureUnknown21(5)Li P<h4>Aim</h4>To investigate the distribution and expression of C-type natriuretic peptide (CNP)/natriuretic peptide receptor B (NPR-B) in the rectum of a rodent depression model and the interventional effect of Xiaoyaosan (XYS).<h4>Methods</h4>Male rats (n = 45) of clean grade (200 ± 20 g) were divided into five groups after one week of adaptive feeding: primary control, depression model, low dose XYS, middle dose XYS, and high dose XYS. The animal experiment continued for 3 wk. Primary controls were fed normally ad libitum. The rats of all other groups were raised in solitary and exposed to classic chronic mild unpredictable stimulation each day. XYS groups were perfused intragastrically with low dose, middle dose, and high dose XYS one hour before stimulation. Primary control and depressiWorld journal of gastroenterology1518-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC4316094biostudies-literatureCNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.PMC4316094Guo HSQiu JJTang XDCai ZXOwusu LLi PLin XLZhu TfalseCNP signal pathway up-regulated in rectum of depressed rats and the interventional effect of Xiaoyaosan.<h4>Aim</h4>To investigate the distribution and expression of C-type natriuretic peptide (CNP)/natriuretic peptide receptor B (NPR-B) in the rectum of a rodent depression model and the interventional effect of Xiaoyaosan (XYS).<h4>Methods</h4>Male rats (n = 45) of clean grade (200 ± 20 g) were divided into five groups after one week of adaptive feeding: primary control, depression model, low dose XYS, middle dose XYS, and high dose XYS. The animal experiment continued for 3 wk. Primary controls were fed normally ad libitum. The rats of all other groups were raised in solitary and exposed to classic chronic mild unpredictable stimulation each day. XYS groups were perfused intragastrically with low dose, middle dose, and high dose XYS one hour before stimulation. Primary control and depressi2015-01-01T00:00:00Z2015 Feb2025-04-25T20:39:28.053Z2020-10-29T09:16:00ZS-EPMC43160942566377110.3748/wjg.v21.i5.1518