{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Zhang Y"],"pubmed_abstract":["The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cells that normally express ROW1. The wox5-1/row1-3 double mutants show similar phenotypes to wox5-1 indicating that WOX5 is epistatic to ROW1. ROW1 specifically binds trimethylated histone H3 lysine 4 (H3K4me3) in the WOX5 promoter region to repress its transcription. QC expression of ROW1 results in a wox5-1-like phenotype with undetectable WOX5 transcripts. We propose that ROW1 is essential for QC maintenance and for stem cell niche development through the repression of WOX5 i"],"journal":["Nature communications"],"pagination":["6003"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4316744"],"repository":["biostudies-literature"],"pubmed_title":["ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells."],"pmcid":["PMC4316744"],"pubmed_authors":["Liu Z","Zhang Y","Zhu YX","Jiao Y"],"additional_accession":[]},"is_claimable":false,"name":"ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.","description":"The quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cells that normally express ROW1. The wox5-1/row1-3 double mutants show similar phenotypes to wox5-1 indicating that WOX5 is epistatic to ROW1. ROW1 specifically binds trimethylated histone H3 lysine 4 (H3K4me3) in the WOX5 promoter region to repress its transcription. QC expression of ROW1 results in a wox5-1-like phenotype with undetectable WOX5 transcripts. We propose that ROW1 is essential for QC maintenance and for stem cell niche development through the repression of WOX5 i","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2025-05-29T21:06:40.598Z","creation":"2019-03-27T01:44:37Z"},"accession":"S-EPMC4316744","cross_references":{"pubmed":["25631790"],"doi":["10.1038/ncomms7003"]}}