{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["105(1)"],"submitter":["Ye J"],"pubmed_abstract":["Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound serine protease inhibitor that is expressed on the surface of epithelial and carcinoma cells. On the cell surface, HAI-1 regulates membrane-anchored serine proteases, with matriptase being the most critical target. Matriptase is involved in pericellular processing of biologically active molecules, including protease-activated receptor-2 (PAR-2). Previously we reported that S2-CP8 cells, a metastatic variant of the SUIT-2 human pancreatic adenocarcinoma cell line, showed markedly decreased HAI-1 expression. To assess the significance of HAI-1 loss in invasion and spontaneous metastasis of S2-CP8 cells, we established stable S2-CP8 sublines that expressed HAI-1 under the control of a tetracycline-regulated promot"],"journal":["Cancer science"],"pagination":["44-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4317873"],"repository":["biostudies-literature"],"pubmed_title":["Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model."],"pmcid":["PMC4317873"],"pubmed_authors":["Kanemaru A","Kawaguchi M","Yamamoto K","Haruyama Y","Ye J","Fukushima T","Lin CY","Kataoka H"],"additional_accession":[]},"is_claimable":false,"name":"Loss of hepatocyte growth factor activator inhibitor type 1 participates in metastatic spreading of human pancreatic cancer cells in a mouse orthotopic transplantation model.","description":"Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a membrane-bound serine protease inhibitor that is expressed on the surface of epithelial and carcinoma cells. On the cell surface, HAI-1 regulates membrane-anchored serine proteases, with matriptase being the most critical target. Matriptase is involved in pericellular processing of biologically active molecules, including protease-activated receptor-2 (PAR-2). Previously we reported that S2-CP8 cells, a metastatic variant of the SUIT-2 human pancreatic adenocarcinoma cell line, showed markedly decreased HAI-1 expression. To assess the significance of HAI-1 loss in invasion and spontaneous metastasis of S2-CP8 cells, we established stable S2-CP8 sublines that expressed HAI-1 under the control of a tetracycline-regulated promot","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2025-04-20T02:51:17.651Z","creation":"2019-03-27T01:44:40Z"},"accession":"S-EPMC4317873","cross_references":{"pubmed":["24147538"],"doi":["10.1111/cas.12306"]}}