biostudies-literatureUnknown16Watanabe N<h4>Background</h4>It is reported that nursing is one of the most vulnerable jobs for developing depression. While they may not be clinically diagnosed as depressed, nurses often suffer from depression and anxiety symptoms, which can lead to a low level of patient care. However, there is no rigorous evidence base for determining an effective prevention strategy for these symptoms in nurses. After reviewing previous literature, we chose a strategy of treatment with omega-3 fatty acids and a mindfulness-based stress management program for this purpose. We aim to explore the effectiveness of these intervention options for junior nurses working in hospital wards in Japan.<h4>Methods/design</h4>A factorial-design multi-center randomized trial is currently being conducted. A total of 120 nurses Trials36https://www.ebi.ac.uk/biostudies/studies/S-EPMC4326519biostudies-literatureA mindfulness-based stress management program and treatment with omega-3 fatty acids to maintain a healthy mental state in hospital nurses (Happy Nurse Project): study protocol for a randomized controlled trial.PMC4326519Matsuoka YKumachi MNoguchi HKatsuki FHorikoshi MHamazaki KNarisawa TWatanabe NOe YFurukawa TAShinmei IfalseA mindfulness-based stress management program and treatment with omega-3 fatty acids to maintain a healthy mental state in hospital nurses (Happy Nurse Project): study protocol for a randomized controlled trial.<h4>Background</h4>It is reported that nursing is one of the most vulnerable jobs for developing depression. While they may not be clinically diagnosed as depressed, nurses often suffer from depression and anxiety symptoms, which can lead to a low level of patient care. However, there is no rigorous evidence base for determining an effective prevention strategy for these symptoms in nurses. After reviewing previous literature, we chose a strategy of treatment with omega-3 fatty acids and a mindfulness-based stress management program for this purpose. We aim to explore the effectiveness of these intervention options for junior nurses working in hospital wards in Japan.<h4>Methods/design</h4>A factorial-design multi-center randomized trial is currently being conducted. A total of 120 nurses 2015-01-01T00:00:00Z2015 Jan2025-04-25T18:20:50.349Z2019-03-27T01:45:08ZS-EPMC43265192563618010.1186/s13063-015-0554-z