{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ansems M"],"funding":["KWF Kankerbestrijding"],"pagination":["693-703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4326655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(3)"],"pubmed_abstract":["Breast cancer is one of the most common causes of cancer-related deaths in women. The estrogen receptor (ERα) is well known for having growth promoting effects in breast cancer. Recently, we have identified DC-SCRIPT (ZNF366) as a co-suppressor of ERα and as a strong and independent prognostic marker in ESR1 (ERα gene)-positive breast cancer patients. In this study, we further investigated the molecular mechanism on how DC-SCRIPT inhibits breast cancer cell growth. DC-SCRIPT mRNA levels from 190 primary ESR1-positive breast tumors were related to global gene expression, followed by gene ontology and pathway analysis. The effect of DC-SCRIPT on breast cancer cell growth and cell cycle arrest was investigated using novel DC-SCRIPT-inducible MCF7 breast cancer cell lines. Genome-wide expressi"],"journal":["Breast cancer research and treatment"],"pubmed_title":["DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells."],"pmcid":["PMC4326655"],"funding_grant_id":["KUN 2011-5229"],"pubmed_authors":["Smid M","de Weerd V","Foekens JA","de Graaf AM","Zuidscherwoude M","Martens JW","Sieuwerts AM","Ansems M","Sondergaard JN","Looman MW","Adema GJ"],"additional_accession":[]},"is_claimable":false,"name":"DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.","description":"Breast cancer is one of the most common causes of cancer-related deaths in women. The estrogen receptor (ERα) is well known for having growth promoting effects in breast cancer. Recently, we have identified DC-SCRIPT (ZNF366) as a co-suppressor of ERα and as a strong and independent prognostic marker in ESR1 (ERα gene)-positive breast cancer patients. In this study, we further investigated the molecular mechanism on how DC-SCRIPT inhibits breast cancer cell growth. DC-SCRIPT mRNA levels from 190 primary ESR1-positive breast tumors were related to global gene expression, followed by gene ontology and pathway analysis. The effect of DC-SCRIPT on breast cancer cell growth and cell cycle arrest was investigated using novel DC-SCRIPT-inducible MCF7 breast cancer cell lines. Genome-wide expressi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Feb","modification":"2026-04-13T08:48:51.349Z","creation":"2019-03-27T01:45:09Z"},"accession":"S-EPMC4326655","cross_references":{"pubmed":["25663546"],"doi":["10.1007/s10549-015-3281-y"]}}