biostudies-literatureLaursen TLDanish Council for Independent Research - Medical SciencesNOVO Nordisk FoundationNIDDK NIH HHSNational Institutes of HealthNovo Nordisk Fonden756-63https://www.ebi.ac.uk/biostudies/studies/S-EPMC4329085biostudies-literatureUnknown35(3)<h4>Background & aims</h4>The complement system is activated in liver diseases including acute liver failure (ALF); however, the role of the lectin pathway of complement has scarcely been investigated in ALF. The pathway is initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL), M-, L-, and H-ficolin and collectin-liver-1 (CL-L1), which are predominantly synthesized in the liver. We aimed to study lectin levels in ALF patients and associations with clinical outcome.<h4>Methods</h4>Serum samples from 75 patients enrolled by the US ALF Study Group were collected on days 1 and 3. We included 75 healthy blood donors and 20 cirrhosis patients as controls. Analyses were performed using sandwich-type immunoassays (ELISA, TRIFMA).<h4>Results</h4>At day 1, the MBL level in Liver international : official journal of the International Association for the Study of the LiverCirculating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure.PMC4329085U01-DK-5836912-132318NNF10OC1013267U01 DK058369NNF13OC0007989Prosser CLalani ELarson AMVilstrup HLaursen TLTaylor WSenkbeil LBernard THay JMcGuire BThiel SPezzia CReuben AEmre SIngram KGronbaek HMurray NFontana RJStoy SPolson JMunoz SWelch SSandahl TDZaman AReddy RCoultrup SSatyanarayana RRush RDavern TJMisra CMcCashland TMGottstein JAvant LPeacock VGroettum CShakil AUS Acute Liver Failure Study GroupCrippin JSHassenein THan SSchiodt FVGerstle LCasson DSchilsky MHuntley NReisch JSHarrison MPartovi KBarakat FBlei ATLee WMChung RSalvatori JSmith ASchwartz JRossaro LMorton DCampbell MStravitz THynan LSBrown RfalseCirculating mannan-binding lectin, M-, L-, H-ficolin and collectin-liver-1 levels in patients with acute liver failure.<h4>Background & aims</h4>The complement system is activated in liver diseases including acute liver failure (ALF); however, the role of the lectin pathway of complement has scarcely been investigated in ALF. The pathway is initiated by soluble pattern recognition molecules: mannan-binding lectin (MBL), M-, L-, and H-ficolin and collectin-liver-1 (CL-L1), which are predominantly synthesized in the liver. We aimed to study lectin levels in ALF patients and associations with clinical outcome.<h4>Methods</h4>Serum samples from 75 patients enrolled by the US ALF Study Group were collected on days 1 and 3. We included 75 healthy blood donors and 20 cirrhosis patients as controls. Analyses were performed using sandwich-type immunoassays (ELISA, TRIFMA).<h4>Results</h4>At day 1, the MBL level in 2015-01-01T00:00:00Z2015 Mar2025-04-04T14:39:41.752Z2019-03-27T01:45:15ZS-EPMC43290852520305710.1111/liv.12682