biostudies-literaturePapatheodorou SINCI NIH HHS353-63https://www.ebi.ac.uk/biostudies/studies/S-EPMC4332790biostudies-literatureUnknown25(3)<h4>Purpose</h4>Sex steroid hormone concentrations and insulin-like growth factor (IGF) proteins have been independently associated with risk of cancer, chronic diseases, and mortality. However, studies that evaluated the inter-relation between the sex hormones and IGF pathways have provided mixed results. We examined the association between endogenous sex hormones and sex hormone-binding globulin (SHBG) with IGF-1 and IGF-binding protein 3 (IGFBP-3) in a population-based sample of US men.<h4>Methods</h4>Data from 1,135 men aged 20 years or older participating in the third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Weighted linear regression was used to estimate geometric means and 95 % confidence intervals for IGF-1 and IGFBP-3 concentrations by sex steroCancer causes & control : CCCAssociation between endogenous sex steroid hormones and insulin-like growth factor proteins in US men.PMC4332790P30 CA006973Joshu CETsilidis KKRohrmann SRifai NKanarek NBradwin GPapatheodorou SILopez DSNelson WGPlatz EAfalseAssociation between endogenous sex steroid hormones and insulin-like growth factor proteins in US men.<h4>Purpose</h4>Sex steroid hormone concentrations and insulin-like growth factor (IGF) proteins have been independently associated with risk of cancer, chronic diseases, and mortality. However, studies that evaluated the inter-relation between the sex hormones and IGF pathways have provided mixed results. We examined the association between endogenous sex hormones and sex hormone-binding globulin (SHBG) with IGF-1 and IGF-binding protein 3 (IGFBP-3) in a population-based sample of US men.<h4>Methods</h4>Data from 1,135 men aged 20 years or older participating in the third National Health and Nutrition Examination Survey (NHANES III) were analyzed. Weighted linear regression was used to estimate geometric means and 95 % confidence intervals for IGF-1 and IGFBP-3 concentrations by sex stero2014-01-01T00:00:00Z2014 Mar2025-04-21T21:14:39.828Z2019-03-27T01:46:40ZS-EPMC43327902439514010.1007/s10552-013-0336-4