{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Most D"],"funding":["NIAAA NIH HHS"],"pagination":["177-88"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4334750"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Chronic alcohol consumption changes gene expression, likely causing persistent remodeling of synaptic structures via altered translation of mRNAs within synaptic compartments of the cell. We profiled the transcriptome from synaptoneurosomes (SNs) and paired total homogenates (THs) from mouse amygdala following chronic voluntary alcohol consumption. In SN, both the number of alcohol-responsive mRNAs and the magnitude of fold-change were greater than in THs, including many GABA-related mRNAs upregulated in SNs. Furthermore, SN gene co-expression analysis revealed a highly connected network, demonstrating coordinated patterns of gene expression and highlighting alcohol-responsive biological pathways, such as long-term potentiation, long-term depression, glutamate signaling, RNA processing and"],"journal":["The pharmacogenomics journal"],"pubmed_title":["The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol."],"pmcid":["PMC4334750"],"funding_grant_id":["P01 AA020683","AA020683","F31 AA022557","U01 AA020926","AA012404","U01 AA013520","1F31-AA022557-01","RC2AA019382","RC2 AA019382","T32 AA007471","R01 AA012404","AA-UO1-13520"],"pubmed_authors":["Most D","Harris RA","Ferguson L","Mayfield RD","Blednov Y"],"additional_accession":[]},"is_claimable":false,"name":"The synaptoneurosome transcriptome: a model for profiling the emolecular effects of alcohol.","description":"Chronic alcohol consumption changes gene expression, likely causing persistent remodeling of synaptic structures via altered translation of mRNAs within synaptic compartments of the cell. We profiled the transcriptome from synaptoneurosomes (SNs) and paired total homogenates (THs) from mouse amygdala following chronic voluntary alcohol consumption. In SN, both the number of alcohol-responsive mRNAs and the magnitude of fold-change were greater than in THs, including many GABA-related mRNAs upregulated in SNs. Furthermore, SN gene co-expression analysis revealed a highly connected network, demonstrating coordinated patterns of gene expression and highlighting alcohol-responsive biological pathways, such as long-term potentiation, long-term depression, glutamate signaling, RNA processing and","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2026-05-03T07:42:20.996Z","creation":"2019-03-27T01:46:46Z"},"accession":"S-EPMC4334750","cross_references":{"pubmed":["25135349"],"doi":["10.1038/tpj.2014.43"]}}