biostudies-literatureUnknown10(2)Smeeing DP<h4>Purpose</h4>To determine the effectiveness and safety of interventions used for rehabilitation after open reduction and internal fixation of ankle fractures.<h4>Methods</h4>A systematic review and meta-analysis was performed using both randomized trials and cohort studies. The effect of mobilization, weight-bearing, and unprotected weight-bearing as tolerated on postoperative recovery was compared using the Olerud Molander score, return to work/daily activities, and the rate of complications.<h4>Results</h4>A total of 25 articles were included. Ankle exercises resulted in earlier return to work and/or daily activities compared to immobilization (mean difference (MD) -20.76 days; 95% confidence interval (CI) -40.02 to -1.50). There was no difference in the rate of complications between exercises and immobilization (risk ratio (RR) 1.22; 95% CI 0.60 to 2.45) or between early and late weight-bearing (RR 1.26; 95%CI 0.56 to 2.85).<h4>Interpretation</h4>Results of this meta-analysis show that following ankle surgery, 1) active exercises accelerate return to work and daily activities compared to immobilization, 2) early weight-bearing tends to accelerate return to work and daily activities compared to late weight-bearing. Active exercises in combination with immediate weight-bearing may be a safe option.PloS onee0118320https://www.ebi.ac.uk/biostudies/studies/S-EPMC4335061biostudies-literatureWeight-bearing and mobilization in the postoperative care of ankle fractures: a systematic review and meta-analysis of randomized controlled trials and cohort studies.PMC4335061Segers MJVerleisdonk EJHouwert RMKelder JCLeenen LPBriet JPHietbrink FSmeeing DPfalseWeight-bearing and mobilization in the postoperative care of ankle fractures: a systematic review and meta-analysis of randomized controlled trials and cohort studies.<h4>Purpose</h4>To determine the effectiveness and safety of interventions used for rehabilitation after open reduction and internal fixation of ankle fractures.<h4>Methods</h4>A systematic review and meta-analysis was performed using both randomized trials and cohort studies. The effect of mobilization, weight-bearing, and unprotected weight-bearing as tolerated on postoperative recovery was compared using the Olerud Molander score, return to work/daily activities, and the rate of complications.<h4>Results</h4>A total of 25 articles were included. Ankle exercises resulted in earlier return to work and/or daily activities compared to immobilization (mean difference (MD) -20.76 days; 95% confidence interval (CI) -40.02 to -1.50). There was no difference in the rate of complications between exercises and immobilization (risk ratio (RR) 1.22; 95% CI 0.60 to 2.45) or between early and late weight-bearing (RR 1.26; 95%CI 0.56 to 2.85).<h4>Interpretation</h4>Results of this meta-analysis show that following ankle surgery, 1) active exercises accelerate return to work and daily activities compared to immobilization, 2) early weight-bearing tends to accelerate return to work and daily activities compared to late weight-bearing. Active exercises in combination with immediate weight-bearing may be a safe option.2015-01-01T00:00:00Z20152024-11-20T17:57:15.105Z2019-03-26T23:30:20ZS-EPMC43350612569579610.1371/journal.pone.0118320