{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ambalavanan N"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NCRR NIH HHS"],"pagination":["F145-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4336211"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["100(2)"],"pubmed_abstract":["<h4>Objective</h4>To determine the association of arterial partial pressure of carbon dioxide PaCO2 with severe intraventricular haemorrhage (sIVH), bronchopulmonary dysplasia (BPD), and neurodevelopmental impairment (NDI) at 18-22 months in premature infants.<h4>Design</h4>Secondary exploratory data analysis of Surfactant, Positive Pressure, and Oxygenation Randomised Trial (SUPPORT).<h4>Setting</h4>Multiple referral neonatal intensive care units.<h4>Patients</h4>1316 infants 24 0/7 to 27 6/7 weeks gestation randomised to different oxygenation (SpO2 target 85-89% vs 91-95%) and ventilation strategies.<h4>Main outcome measures</h4>Blood gases from postnatal day 0 to day14 were analysed. Five PaCO2 variables were defined: minimum (Min), maximum (Max), SD, average (time-weighted), and a four"],"journal":["Archives of disease in childhood. Fetal and neonatal edition"],"pubmed_title":["PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT)."],"pmcid":["PMC4336211"],"funding_grant_id":["UG1 HD068278","UL1 TR001085","M01 RR30","U10 HD027904","M01 RR000070","M01 RR70","UL1 TR142","U10 HD053119","U10 HD21397","U10 HD27856","M01 RR016587","UG1 HD034216","M01 RR39","U10 HD27853","U10 HD53119","UG1 HD027851","U10 HD27851","M01 RR16587","U10 HD021364","U10 HD040521","M01 RR32","UG1 HD087229","U10 HD040689","UL1 TR000442","U10 HD053109","U10 HD53124","U10 HD27904","UG1 HD053089","U10 HD53089","U10 HD21364","U10 HD027871","U10 HD021373","M01 RR64","UL1 TR000093","U10 HD40461","UG1 HD021364","M01 RR125","UL1 TR000371","UL1 TR000454","U10 HD040461","U10 HD34216","U10 HD36790","UL1 TR442","M01 RR8084","U10 HD21373","U10 HD027880","U10 HD27871","U10 HD021385","U10 HD40498","M01 RR59","M01 RR6022","UL1 TR93","M01 RR54","M01 RR007122","U10 HD40492","UG1 HD040492","U10 HD036790","UL1 TR000142","U10 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S","Buchter S","Morris MW","Poulsen J","Cosby SS","Lacy CB","Salhab WA","Chiu K","DeBattista AM","Green C","Miller NA","Stroerger A","Huitema CP","Hamer F","Finer NN","Weiss HE","McGowan EC","Whitely LL","Stoll BJ","Newman JE","Friedman HG","Pierre H","Butler CG","Proud MS","Sanchez PJ","Fisher KA","Adams SS","Carlo WA","Lemons JA","Auten KJ","Gustafson KE","Gettner P","Hessling J","Boatman CT","Patterson CS","Madden LA","Hounshell GW","Van Meurs KP","Furey A","Romano E","Eguaras SM","Johnson JB","Spencer C","Lainwala S","Steffen M","Biasini FJ","Yost K","Faix RG","Reddoch S","Wallace D","Garcia A","Stevenson DK","Johnson K","Higgins RD","Myers GJ","Whitley S","Goldston LA","Eastman DL","Close N","Sibley C","Heyne ET","Yoder BA","Bridge R","Everett-Thomas R","St John NH","Mersmann MW","Kennedy KA","Ashley PL","Newman NS","Frantz ID","Rasmussen MR","Allred DE","Mathews EE","SUPPORT Study Group of the NICHD Neonatal Research Network","Krzywanski S","Morris BH","Poindexter BB","Zlotnik P","Hamlin-Smith K","Hintz SR","Foy KA","Alaniz NI","Brion LP","Siner BS","MacKinnon BL","Evans PW","McDavid GE","Poole WK","Rector RV","Noel L","Adams-Chapman I","Berkowits MH","Zaterka-Baxter KM","Vaucher YE","Torres LE","Carter SL","Harris BF","Martin S","Jacobs HC","Alksninis B","Di Fiore J","Heyne RJ","Peterson C","Lytle C","Soong AD","Sood BG","Nylen E","Malcolm WF","Pyle RP","Watson VE","Laptook AR","Welch CD","Gilliam W","LaRossa MM","Montman R","Vohr BR","Colaizy TT","Ehrenkranz RA","Wilson LD","Caskey M","Hale EC","Bridges K","Cashore WJ","Fuller MG","Bhandari V","Collins MV","Jobe AH","Kohn JG","Arnell K","Taft J","Cervone P","Walden RV","Widness JA","Zadell A","Bell EF","Davis AS","Pickett JW","Burnell E","Waldrep EL","Hust D","Allen J","Caplan MS","Yolton K","Grau L","Baker S","Wilson-Costello DE","Carlton DP","Konstantino M","Wallace DK","Vasil DM","Hensley G","Wozniak PR","Bhola M","Hensman AM","Mincey HL","Osborne KA","Burnett J","Hastings BK","Wright SL","Gargus RA","Wrage LA","Leonard MR","Lowe J","Laughon M","Lis AE","Bara R","Greisman S","Lohmeyer MB","Ohls RK","Shankaran S","Reubens LJ","Freedman SF","Bailey KJ","Gantz MG","Yalcinkaya G","Donovan EF","Johnston KC","York SC","Leps MH","Goldstein DJ","Rich W","Acarregui MJ","Weaver-Lewis K","Alexander B","Oh W","Washburn LK","Merzbach J","Hutchinson AK","Gratton TL","Moore JR","Dillard RG","Archer SW","Auman JO","DeAnda ME","Minnich HM","Halfond R","Klein JM","Das A","Leach TM","Phillips VA","Piazza AJ","Rosenfeld CR","Fuller J"],"additional_accession":[]},"is_claimable":false,"name":"PaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT).","description":"<h4>Objective</h4>To determine the association of arterial partial pressure of carbon dioxide PaCO2 with severe intraventricular haemorrhage (sIVH), bronchopulmonary dysplasia (BPD), and neurodevelopmental impairment (NDI) at 18-22 months in premature infants.<h4>Design</h4>Secondary exploratory data analysis of Surfactant, Positive Pressure, and Oxygenation Randomised Trial (SUPPORT).<h4>Setting</h4>Multiple referral neonatal intensive care units.<h4>Patients</h4>1316 infants 24 0/7 to 27 6/7 weeks gestation randomised to different oxygenation (SpO2 target 85-89% vs 91-95%) and ventilation strategies.<h4>Main outcome measures</h4>Blood gases from postnatal day 0 to day14 were analysed. Five PaCO2 variables were defined: minimum (Min), maximum (Max), SD, average (time-weighted), and a four","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2025-06-28T03:05:22.174Z","creation":"2025-06-28T03:05:22.174Z"},"accession":"S-EPMC4336211","cross_references":{"pubmed":["25425651"],"doi":["10.1136/archdischild-2014-306802"]}}