biostudies-literatureAmbalavanan NNICHD NIH HHSNCATS NIH HHSNCRR NIH HHSF145-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4336211biostudies-literatureUnknown100(2)<h4>Objective</h4>To determine the association of arterial partial pressure of carbon dioxide PaCO2 with severe intraventricular haemorrhage (sIVH), bronchopulmonary dysplasia (BPD), and neurodevelopmental impairment (NDI) at 18-22 months in premature infants.<h4>Design</h4>Secondary exploratory data analysis of Surfactant, Positive Pressure, and Oxygenation Randomised Trial (SUPPORT).<h4>Setting</h4>Multiple referral neonatal intensive care units.<h4>Patients</h4>1316 infants 24 0/7 to 27 6/7 weeks gestation randomised to different oxygenation (SpO2 target 85-89% vs 91-95%) and ventilation strategies.<h4>Main outcome measures</h4>Blood gases from postnatal day 0 to day14 were analysed. Five PaCO2 variables were defined: minimum (Min), maximum (Max), SD, average (time-weighted), and a fourArchives of disease in childhood. Fetal and neonatal editionPaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT).PMC4336211UG1 HD068278UL1 TR001085M01 RR30U10 HD027904M01 RR000070M01 RR70UL1 TR142U10 HD053119U10 HD21397U10 HD27856M01 RR016587UG1 HD034216M01 RR39U10 HD27853U10 HD53119UG1 HD027851U10 HD27851M01 RR16587U10 HD021364U10 HD040521M01 RR32UG1 HD087229U10 HD040689UL1 TR000442U10 HD053109U10 HD53124U10 HD27904UG1 HD053089U10 HD53089U10 HD21364U10 HD027871U10 HD021373M01 RR64UL1 TR000093U10 HD40461UG1 HD021364M01 RR125UL1 TR000371UL1 TR000454U10 HD040461U10 HD34216U10 HD36790UL1 TR442M01 RR8084U10 HD21373U10 HD027880U10 HD27871U10 HD021385U10 HD40498M01 RR59M01 RR6022UL1 TR93M01 RR54M01 RR007122U10 HD40492UG1 HD040492U10 HD036790UL1 TR000142U10 HD040498M01 RR750U10 HD040492UG1 HD053109U10 HD40689M01 RR80U10 HD40521M01 RR997M01 RR633UL1 TR454U10 HD034216U10 HD53109U10 HD053124U10 HD027851U10 HD21385M01 RR008084U10 HD053089U10 HD027856U10 HD021397M01 RR7122U10 HD027853UG1 HD027880M01 RR44U10 HD27880Nelson KGBentley BGrisby CFanaroff AABruno EFFiascone JMWilliams JSolis ARodrigues LJohnson MEDiaz ANMorgan JSMartin MSPeters NJHerron DEMarkowitz GDSchibler KGoldstein RFFajardo-Hiriart SKushner EGingras DJLillie SCalejo MStephens BEJiminez MCook ABDemetrio CAmbalavanan NWatterberg KLCotten CMDuara SDusick AMWalsh MCTyson JEGoldberg RNBall MBPeralta-Carcelen MO'Shea TMPappas ABrussa ABauer CRPhelps DLJensen RLTate PLJohnson KJGuzman ABarnett SGPoundstone MLJackson BGRiguard ABird KSiddiki SBuchter SMorris MWPoulsen JCosby SSLacy CBSalhab WAChiu KDeBattista AMGreen CMiller NAStroerger AHuitema CPHamer FFiner NNWeiss HEMcGowan ECWhitely LLStoll BJNewman JEFriedman HGPierre HButler CGProud MSSanchez PJFisher KAAdams SSCarlo WALemons JAAuten KJGustafson KEGettner PHessling JBoatman CTPatterson CSMadden LAHounshell GWVan Meurs KPFurey ARomano EEguaras SMJohnson JBSpencer CLainwala SSteffen MBiasini FJYost KFaix RGReddoch SWallace DGarcia AStevenson DKJohnson KHiggins RDMyers GJWhitley SGoldston LAEastman DLClose NSibley CHeyne ETYoder BABridge REverett-Thomas RSt John NHMersmann MWKennedy KAAshley PLNewman NSFrantz IDRasmussen MRAllred DEMathews EESUPPORT Study Group of the NICHD Neonatal Research NetworkKrzywanski SMorris BHPoindexter BBZlotnik PHamlin-Smith KHintz SRFoy KAAlaniz NIBrion LPSiner BSMacKinnon BLEvans PWMcDavid GEPoole WKRector RVNoel LAdams-Chapman IBerkowits MHZaterka-Baxter KMVaucher YETorres LECarter SLHarris BFMartin SJacobs HCAlksninis BDi Fiore JHeyne RJPeterson CLytle CSoong ADSood BGNylen EMalcolm WFPyle RPWatson VELaptook ARWelch CDGilliam WLaRossa MMMontman RVohr BRColaizy TTEhrenkranz RAWilson LDCaskey MHale ECBridges KCashore WJFuller MGBhandari VCollins MVJobe AHKohn JGArnell KTaft JCervone PWalden RVWidness JAZadell ABell EFDavis ASPickett JWBurnell EWaldrep ELHust DAllen JCaplan MSYolton KGrau LBaker SWilson-Costello DECarlton DPKonstantino MWallace DKVasil DMHensley GWozniak PRBhola MHensman AMMincey HLOsborne KABurnett JHastings BKWright SLGargus RAWrage LALeonard MRLowe JLaughon MLis AEBara RGreisman SLohmeyer MBOhls RKShankaran SReubens LJFreedman SFBailey KJGantz MGYalcinkaya GDonovan EFJohnston KCYork SCLeps MHGoldstein DJRich WAcarregui MJWeaver-Lewis KAlexander BOh WWashburn LKMerzbach JHutchinson AKGratton TLMoore JRDillard RGArcher SWAuman JODeAnda MEMinnich HMHalfond RKlein JMDas ALeach TMPhillips VAPiazza AJRosenfeld CRFuller JfalsePaCO2 in surfactant, positive pressure, and oxygenation randomised trial (SUPPORT).<h4>Objective</h4>To determine the association of arterial partial pressure of carbon dioxide PaCO2 with severe intraventricular haemorrhage (sIVH), bronchopulmonary dysplasia (BPD), and neurodevelopmental impairment (NDI) at 18-22 months in premature infants.<h4>Design</h4>Secondary exploratory data analysis of Surfactant, Positive Pressure, and Oxygenation Randomised Trial (SUPPORT).<h4>Setting</h4>Multiple referral neonatal intensive care units.<h4>Patients</h4>1316 infants 24 0/7 to 27 6/7 weeks gestation randomised to different oxygenation (SpO2 target 85-89% vs 91-95%) and ventilation strategies.<h4>Main outcome measures</h4>Blood gases from postnatal day 0 to day14 were analysed. Five PaCO2 variables were defined: minimum (Min), maximum (Max), SD, average (time-weighted), and a four2015-01-01T00:00:00Z2015 Mar2025-06-28T03:05:22.174Z2025-06-28T03:05:22.174ZS-EPMC43362112542565110.1136/archdischild-2014-306802