{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jiang B"],"funding":["NIDA NIH HHS"],"pagination":["3656-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4337423"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(14)"],"pubmed_abstract":["Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2-aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed."],"journal":["Organic letters"],"pubmed_title":["Copper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives."],"pmcid":["PMC4337423"],"funding_grant_id":["R33 DA031860","R33DA031860"],"pubmed_authors":["Li G","Tu SJ","Tu XJ","Jiang B","Wang X"],"additional_accession":[]},"is_claimable":false,"name":"Copper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives.","description":"Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2-aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2021-02-21T06:09:21Z","creation":"2019-03-27T01:46:55Z"},"accession":"S-EPMC4337423","cross_references":{"pubmed":["24988049"],"doi":["10.1021/ol501404x"]}}