biostudies-literatureJiang BNIDA NIH HHS3656-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4337423biostudies-literatureUnknown16(14)Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2-aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.Organic lettersCopper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives.PMC4337423R33 DA031860R33DA031860Li GTu SJTu XJJiang BWang XfalseCopper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives.Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2-aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.2014-01-01T00:00:00Z2014 Jul2021-02-21T06:09:21Z2019-03-27T01:46:55ZS-EPMC43374232498804910.1021/ol501404x