{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(2)"],"submitter":["Erives AJ"],"pubmed_abstract":["The evolution of animals involved acquisition of an emergent gene repertoire for gastrulation. Whether loss of genes also co-evolved with this developmental reprogramming has not yet been addressed. Here, we identify twenty-four genetic functions that are retained in fungi and choanoflagellates but undetectable in animals. These lost genes encode: (i) sixteen distinct biosynthetic functions; (ii) the two ancestral eukaryotic ClpB disaggregases, Hsp78 and Hsp104, which function in the mitochondria and cytosol, respectively; and (iii) six other assorted functions. We present computational and experimental data that are consistent with a joint function for the differentially localized ClpB disaggregases, and with the possibility of a shared client/chaperone relationship between the mitochondr"],"journal":["PloS one"],"pagination":["e0117192"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4339202"],"repository":["biostudies-literature"],"pubmed_title":["Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients."],"pmcid":["PMC4339202"],"pubmed_authors":["Erives AJ","Fassler JS"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients.","description":"The evolution of animals involved acquisition of an emergent gene repertoire for gastrulation. Whether loss of genes also co-evolved with this developmental reprogramming has not yet been addressed. Here, we identify twenty-four genetic functions that are retained in fungi and choanoflagellates but undetectable in animals. These lost genes encode: (i) sixteen distinct biosynthetic functions; (ii) the two ancestral eukaryotic ClpB disaggregases, Hsp78 and Hsp104, which function in the mitochondria and cytosol, respectively; and (iii) six other assorted functions. We present computational and experimental data that are consistent with a joint function for the differentially localized ClpB disaggregases, and with the possibility of a shared client/chaperone relationship between the mitochondr","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-04-13T14:07:22.995Z","creation":"2019-03-26T23:30:24Z"},"accession":"S-EPMC4339202","cross_references":{"pubmed":["25710177"],"doi":["10.1371/journal.pone.0117192"]}}