{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim M"],"funding":["NCRR NIH HHS","NINDS NIH HHS","NIH","NIGMS NIH HHS"],"pagination":["68-79"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4339514"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["399(1)"],"pubmed_abstract":["Motor neurons differentiate from a ventral column of progenitors and settle in static clusters, the motor nuclei, next to the floor plate. Within these cell clusters, motor neurons receive afferent input and project their axons out to muscle targets. The molecular mechanisms that position motor neurons in the neural tube remain poorly understood. The floor plate produces several types of guidance cues with well-known roles in attracting and repelling axons, including the Slit family of chemorepellents via their Robo receptors, and Netrin1 via its DCC attractive receptor. In the present study we found that Islet1(+) motor neuron cell bodies invaded the floor plate of Robo1/2 double mutant mouse embryos or Slit1/2/3 triple mutants. Misplaced neurons were born in their normal progenitor colum"],"journal":["Developmental biology"],"pubmed_title":["Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction."],"pmcid":["PMC4339514"],"funding_grant_id":["P20GM103650","P20RR-016464","R21 NS077169","P20GM103554","R21NS077169","P20 GM103554","R01 NS054740","NIHRO1NS054740","P20 RR016464","P20 GM103440","P20 GM103650"],"pubmed_authors":["Roesener AP","Mastick GS","Gurung S","Mendonca PRF","Lee H","Kim M","Fontelonga T"],"additional_accession":[]},"is_claimable":false,"name":"Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction.","description":"Motor neurons differentiate from a ventral column of progenitors and settle in static clusters, the motor nuclei, next to the floor plate. Within these cell clusters, motor neurons receive afferent input and project their axons out to muscle targets. The molecular mechanisms that position motor neurons in the neural tube remain poorly understood. The floor plate produces several types of guidance cues with well-known roles in attracting and repelling axons, including the Slit family of chemorepellents via their Robo receptors, and Netrin1 via its DCC attractive receptor. In the present study we found that Islet1(+) motor neuron cell bodies invaded the floor plate of Robo1/2 double mutant mouse embryos or Slit1/2/3 triple mutants. Misplaced neurons were born in their normal progenitor colum","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2025-04-04T14:40:15.969Z","creation":"2019-03-27T01:47:02Z"},"accession":"S-EPMC4339514","cross_references":{"pubmed":["25530182"],"doi":["10.1016/j.ydbio.2014.12.014"]}}