{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weljie AM"],"funding":["NCATS NIH HHS","Howard Hughes Medical Institute","NHLBI NIH HHS","National Aeronautics and Space Administration","NINR NIH HHS","NINDS NIH HHS","HHS | NIH | National Institute of Nursing Research","DOD | Defense Advanced Research Projects Agency","Department of Navy, Office of Naval Research Award"],"pagination":["2569-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4345602"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(8)"],"pubmed_abstract":["Sleep is an essential biological process that is thought to have a critical role in metabolic regulation. In humans, reduced sleep duration has been associated with risk for metabolic disorders, including weight gain, diabetes, obesity, and cardiovascular disease. However, our understanding of the molecular mechanisms underlying effects of sleep loss is only in its nascent stages. In this study we used rat and human models to simulate modern-day conditions of restricted sleep and addressed cross-species consequences via comprehensive metabolite profiling. Serum from sleep-restricted rats was analyzed using polar and nonpolar methods in two independent datasets (n = 10 per study, 3,380 measured features, 407 identified). A total of 38 features were changed across independent experiments, wi"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt."],"pmcid":["PMC4345602"],"funding_grant_id":["UL1TR000003","K08 NS090461","UL1 TR000003","NCC 9-58","T32 HL007713","W911NF1010093","N00014-11-1-0361","R01 NR004281","-","NNX14AN49G"],"pubmed_authors":["Abel T","Weljie AM","Sehgal A","Kayser MS","Birnbaum MJ","Meerlo P","Dinges DF","Goel N","Sengupta A"],"additional_accession":[]},"is_claimable":false,"name":"Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.","description":"Sleep is an essential biological process that is thought to have a critical role in metabolic regulation. In humans, reduced sleep duration has been associated with risk for metabolic disorders, including weight gain, diabetes, obesity, and cardiovascular disease. However, our understanding of the molecular mechanisms underlying effects of sleep loss is only in its nascent stages. In this study we used rat and human models to simulate modern-day conditions of restricted sleep and addressed cross-species consequences via comprehensive metabolite profiling. Serum from sleep-restricted rats was analyzed using polar and nonpolar methods in two independent datasets (n = 10 per study, 3,380 measured features, 407 identified). A total of 38 features were changed across independent experiments, wi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Feb","modification":"2026-05-03T06:57:51.108Z","creation":"2026-04-07T18:59:35.788Z"},"accession":"S-EPMC4345602","cross_references":{"pubmed":["25675494"],"doi":["10.1073/pnas.1417432112"]}}