{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Susi H"],"funding":["European Research Council","Wellcome Trust"],"pagination":["5975"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4354079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6"],"pubmed_abstract":["Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections to have major consequences for both within- and between-host disease dynamics, but data are currently scarce. Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. A spore-trapping experiment demonstrates that co-infected hosts shed more transmission propagules than singly infected hosts, thereby explaining the observed change in epidemiological dynamics. Our experimental findings are confirmed in natural pathogen populations-more devastating epidemics were measured in populations with higher levels of co-infection. Jointly, our results confirm the predictions made by theoretical and experimental studies for the potential of co-infection to alter disease dynamics across a large host-pathogen metapopulation."],"journal":["Nature communications"],"pubmed_title":["Co-infection alters population dynamics of infectious disease."],"pmcid":["PMC4354079"],"funding_grant_id":["281517","095831"],"pubmed_authors":["Barres B","Susi H","Vale PF","Laine AL"],"additional_accession":[]},"is_claimable":false,"name":"Co-infection alters population dynamics of infectious disease.","description":"Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections to have major consequences for both within- and between-host disease dynamics, but data are currently scarce. Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. A spore-trapping experiment demonstrates that co-infected hosts shed more transmission propagules than singly infected hosts, thereby explaining the observed change in epidemiological dynamics. Our experimental findings are confirmed in natural pathogen populations-more devastating epidemics were measured in populations with higher levels of co-infection. Jointly, our results confirm the predictions made by theoretical and experimental studies for the potential of co-infection to alter disease dynamics across a large host-pathogen metapopulation.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2025-04-21T20:35:53.265Z","creation":"2019-03-27T01:47:51Z"},"accession":"S-EPMC4354079","cross_references":{"pubmed":["25569306"],"doi":["10.1038/ncomms6975"]}}