{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(2)"],"submitter":["Zhou M"],"pubmed_abstract":["Chronic myeloid leukemia in the blastic phase (CML-BP) responds poorly to clinical treatments and is usually fatal. In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP. The RBP2 histone demethylase stimulates leukemia cell differentiation and inhibits cell proliferation. We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells. By binding to miR-21 promoter and by demethylating of trimethylated H3K4 at the miR-21 locus, RBP2 downregulated miR-21 expression. This in turn activated PDCD4. In conclusion, RBP2 epigenetically downregulated miR-21 in blast transformation of CML."],"journal":["Oncotarget"],"pagination":["1249-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4359230"],"repository":["biostudies-literature"],"pubmed_title":["Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia."],"pmcid":["PMC4359230"],"pubmed_authors":["Zhou M","Huang T","Zeng J","Sun T","Fu Y","Wang X","Chen C","Jia J"],"additional_accession":[]},"is_claimable":false,"name":"Histone demethylase RBP2 decreases miR-21 in blast crisis of chronic myeloid leukemia.","description":"Chronic myeloid leukemia in the blastic phase (CML-BP) responds poorly to clinical treatments and is usually fatal. In this study, we found that the histone H3 lysine 4 (H3K4) demethylase RBP2 (also called JARID1A and KDM5A) is underexpressed in CML-BP. The RBP2 histone demethylase stimulates leukemia cell differentiation and inhibits cell proliferation. We identified miR-21 was directly downregulated by RBP2 and found that miR-21 downregulated PDCD4 expression in leukemia cells. By binding to miR-21 promoter and by demethylating of trimethylated H3K4 at the miR-21 locus, RBP2 downregulated miR-21 expression. This in turn activated PDCD4. In conclusion, RBP2 epigenetically downregulated miR-21 in blast transformation of CML.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2025-04-18T15:46:33.737Z","creation":"2019-03-27T01:48:10Z"},"accession":"S-EPMC4359230","cross_references":{"pubmed":["25575817"],"doi":["10.18632/oncotarget.2859"]}}