biostudies-literatureChen DAHA Scientist Development GrantNIBIB NIH HHSNCRR NIH HHSNHLBI NIH HHSNIHGCRCEdythe L. Broad Women&apos;s Heart Research FellowshipNIBIB765-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC4362861biostudies-literatureUnknown74(3)<h4>Purpose</h4>MR myocardial perfusion imaging is dependent on reliable electrocardiogram (ECG) triggering for accurate measurement of myocardial blood flow (MBF). A non-ECG-triggered method for quantitative first-pass imaging may improve clinical feasibility in patients with poor ECG signal. The purpose of this study is to evaluate the feasibility of a non-ECG-triggered method for myocardial perfusion imaging in a single slice.<h4>Methods</h4>The proposed non-ECG-triggered technique uses a saturation-recovery magnetization preparation and golden-angle radial acquisition for integrated arterial input function (AIF) measurement. Image based self-gating with a temporal resolution of 42.6 ms is used to generate a first-pass image series with consistent cardiac phase. The AIF is measured using beat-by-beat T1 estimation of the ventricular blood pool. The proposed technique was performed on 14 healthy volunteers and compared against a conventional ECG-triggered dual-bolus acquisition.<h4>Results</h4>The proposed method produced MBF with no significant difference compared with ECG-triggered technique (mean of 0.63 ± 0.22 mL/min/g to 0.73 ± 0.21 mL/min/g).<h4>Conclusion</h4>We have developed a non-ECG-triggered perfusion imaging method with T1 based measurement of the AIF in a single slice. In this preliminary study, our results demonstrate that MBF measured using the proposed method is comparable to the conventional ECG-triggered method.Magnetic resonance in medicineQuantification of myocardial blood flow using non-ECG-triggered MR imaging.PMC4362861R01 HL124649MO1-RR00425EB002623UN55ES6580FM01 RR000425RO1 EB002623T32 EB51705K99 HL124323R01 EB002623M01-RR0042514SDG20480123Bairey Merz CNSharif BThomson LEDharmakumar RLi DChen DBerman DSfalseQuantification of myocardial blood flow using non-ECG-triggered MR imaging.<h4>Purpose</h4>MR myocardial perfusion imaging is dependent on reliable electrocardiogram (ECG) triggering for accurate measurement of myocardial blood flow (MBF). A non-ECG-triggered method for quantitative first-pass imaging may improve clinical feasibility in patients with poor ECG signal. The purpose of this study is to evaluate the feasibility of a non-ECG-triggered method for myocardial perfusion imaging in a single slice.<h4>Methods</h4>The proposed non-ECG-triggered technique uses a saturation-recovery magnetization preparation and golden-angle radial acquisition for integrated arterial input function (AIF) measurement. Image based self-gating with a temporal resolution of 42.6 ms is used to generate a first-pass image series with consistent cardiac phase. The AIF is measured using beat-by-beat T1 estimation of the ventricular blood pool. The proposed technique was performed on 14 healthy volunteers and compared against a conventional ECG-triggered dual-bolus acquisition.<h4>Results</h4>The proposed method produced MBF with no significant difference compared with ECG-triggered technique (mean of 0.63 ± 0.22 mL/min/g to 0.73 ± 0.21 mL/min/g).<h4>Conclusion</h4>We have developed a non-ECG-triggered perfusion imaging method with T1 based measurement of the AIF in a single slice. In this preliminary study, our results demonstrate that MBF measured using the proposed method is comparable to the conventional ECG-triggered method.2015-01-01T00:00:00Z2015 Sep2024-11-09T10:58:10.288Z2019-03-27T01:48:19ZS-EPMC43628612522793510.1002/mrm.25451