{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Merkely B"],"funding":["British Heart Foundation","National Centre for the Replacement, Refinement and Reduction of Animals in Research","Medical Research Council"],"pagination":["869-78"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4367527"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(7)"],"pubmed_abstract":["Vascular derivatives of human embryonic stem cells (hESC) are being developed as sources of tissue-specific cells for organ regeneration. However, identity of developmental pathways that modulate the specification of endothelial cells is not known yet. We studied phosphatidylinositol 3-kinase (PI3K)-Forkhead box O transcription factor 1A (FOXO1A) pathways during differentiation of hESC toward endothelial lineage and on proliferation, maturation, and cell death of hESC-derived endothelial cells (hESC-EC). During differentiation of hESC, expression of FOXO1A transcription factor was linked to the expression of a cluster of angiogenesis- and vascular remodeling-related genes. PI3K inhibitor LY294002 activated FOXO1A and induced formation of CD31(+) hESC-EC. In contrast, differentiating hESC w"],"journal":["Stem cells and development"],"pubmed_title":["Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells."],"pmcid":["PMC4367527"],"funding_grant_id":["RG/14/1/30588","MR/L012618/1","G1000035/1"],"pubmed_authors":["Nemeth T","Mioulane M","Varady G","Merkely B","Zhou W","Harding SE","Lendvai Z","Skopal J","Kosztin A","Foldes G","Leja T","Bagyura Z","Gara E"],"additional_accession":[]},"is_claimable":false,"name":"Signaling via PI3K/FOXO1A pathway modulates formation and survival of human embryonic stem cell-derived endothelial cells.","description":"Vascular derivatives of human embryonic stem cells (hESC) are being developed as sources of tissue-specific cells for organ regeneration. However, identity of developmental pathways that modulate the specification of endothelial cells is not known yet. We studied phosphatidylinositol 3-kinase (PI3K)-Forkhead box O transcription factor 1A (FOXO1A) pathways during differentiation of hESC toward endothelial lineage and on proliferation, maturation, and cell death of hESC-derived endothelial cells (hESC-EC). During differentiation of hESC, expression of FOXO1A transcription factor was linked to the expression of a cluster of angiogenesis- and vascular remodeling-related genes. PI3K inhibitor LY294002 activated FOXO1A and induced formation of CD31(+) hESC-EC. In contrast, differentiating hESC w","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2026-05-03T06:59:49.815Z","creation":"2026-04-07T19:02:11.179Z"},"accession":"S-EPMC4367527","cross_references":{"pubmed":["25387407"],"doi":["10.1089/scd.2014.0247"]}}