biostudies-literatureUnknown9(3)Talaat KRIntramural NIH HHS<h4>Background</h4>The disease course of human immunodeficiency virus (HIV) is often altered by existing or newly acquired coincident infections.<h4>Methodology/principal findings</h4>To assess the influence of pre-existing Wuchereria bancrofti infection on HIV progression, we performed a case-controlled treatment study of HIV positive individuals with (FIL+) or without (FIL-) W. bancrofti infection. Twenty-eight HIV+/FIL+ and 51 matched HIV+/FIL- subjects were treated with a single dose of diethylcarbamazine and albendazole (DEC/Alb) and followed for a year at regular intervals. Sixteen of the HIV+/FIL+ subjects (54%) and 28 of the HIV+/FIL- controls (57%) were on antiretroviral therapy (ART) during the study. Following treatment, no differences were noted in clinical outcomes between thePLoS neglected tropical diseasese0003622https://www.ebi.ac.uk/biostudies/studies/S-EPMC4368731biostudies-literatureTreatment of W. bancrofti (Wb) in HIV/Wb coinfections in South India.PMC4368731Babu SArumugam JDhakshinamurthy KFay MPSwaminathan SPoongulali SGu WTalaat KRSharma JSrinivasan RKumarasamy NMenon PNutman TBfalseTreatment of W. bancrofti (Wb) in HIV/Wb coinfections in South India.<h4>Background</h4>The disease course of human immunodeficiency virus (HIV) is often altered by existing or newly acquired coincident infections.<h4>Methodology/principal findings</h4>To assess the influence of pre-existing Wuchereria bancrofti infection on HIV progression, we performed a case-controlled treatment study of HIV positive individuals with (FIL+) or without (FIL-) W. bancrofti infection. Twenty-eight HIV+/FIL+ and 51 matched HIV+/FIL- subjects were treated with a single dose of diethylcarbamazine and albendazole (DEC/Alb) and followed for a year at regular intervals. Sixteen of the HIV+/FIL+ subjects (54%) and 28 of the HIV+/FIL- controls (57%) were on antiretroviral therapy (ART) during the study. Following treatment, no differences were noted in clinical outcomes between the2015-01-01T00:00:00Z2015 Mar2025-05-18T13:17:48.625Z2025-05-18T13:17:48.625ZS-EPMC43687312579393310.1371/journal.pntd.0003622