{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["van der Linden L"],"funding":["NIAID NIH HHS"],"pagination":["e1004733"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4370873"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(3)"],"pubmed_abstract":["The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and enterovirus 71) for which no antiviral drugs are available. The viral RNA-dependent RNA polymerase is an attractive target for antiviral therapy. Nucleoside-based inhibitors have broad-spectrum activity but often exhibit off-target effects. Most non-nucleoside inhibitors (NNIs) target surface cavities, which are structurally more flexible than the nucleotide-binding pocket, and hence have a more narrow spectrum of activity and are more prone to resistance development. Here, we report a novel NNI, GPC-N114 (2,2'-[(4-chloro-1,2-phenylene)bis(oxy)]bis(5-nitro-benzonitrile)) with broad-spectrum activity against enteroviruses and cardioviruses (another ge"],"journal":["PLoS pathogens"],"pubmed_title":["The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family."],"pmcid":["PMC4370873"],"funding_grant_id":["R01 AI104878"],"pubmed_authors":["van Kuppeveld FJ","Lanke K","Leyssen P","Ulferts R","De Palma AM","Coutard B","Canard B","Lefebvre D","Purstinger G","Ferrer-Orta C","De Clercq K","Arnold JJ","van der Linden L","Liu X","Selisko B","Cameron CE","Neyts J","Vives-Adrian L","Verdaguer N","Boehr DD","Tanchis F","Goris N","Lacroix C"],"additional_accession":[]},"is_claimable":false,"name":"The RNA template channel of the RNA-dependent RNA polymerase as a target for development of antiviral therapy of multiple genera within a virus family.","description":"The genus Enterovirus of the family Picornaviridae contains many important human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and enterovirus 71) for which no antiviral drugs are available. The viral RNA-dependent RNA polymerase is an attractive target for antiviral therapy. Nucleoside-based inhibitors have broad-spectrum activity but often exhibit off-target effects. Most non-nucleoside inhibitors (NNIs) target surface cavities, which are structurally more flexible than the nucleotide-binding pocket, and hence have a more narrow spectrum of activity and are more prone to resistance development. Here, we report a novel NNI, GPC-N114 (2,2'-[(4-chloro-1,2-phenylene)bis(oxy)]bis(5-nitro-benzonitrile)) with broad-spectrum activity against enteroviruses and cardioviruses (another ge","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2026-04-08T00:46:33.141Z","creation":"2019-03-26T22:43:15Z"},"accession":"S-EPMC4370873","cross_references":{"pubmed":["25799064"],"doi":["10.1371/journal.ppat.1004733"]}}