biostudies-literatureUnknown10(3)Hapuarachchi HCThe exact mechanisms of interplay between host and viral factors leading to severe dengue are yet to be fully understood. Even though previous studies have implicated specific genetic differences of Dengue virus (DENV) in clinical severity and virus attenuation, similar studies with large-scale, whole genome screening of monophyletic virus populations are limited. Therefore, in the present study, we compared 89 whole genomes of DENV-2 cosmopolitan clade III isolates obtained from patients diagnosed with dengue fever (DF, n = 58), dengue hemorrhagic fever (DHF, n = 30) and dengue shock syndrome (DSS, n = 1) in Singapore between July 2010 and January 2013, in order to determine the correlation of observed viral genetic differences with clinical outcomes. Our findings showed no significant diPloS onee0121696https://www.ebi.ac.uk/biostudies/studies/S-EPMC4374945biostudies-literatureClinical outcome and genetic differences within a monophyletic Dengue virus type 2 population.PMC4374945Lye DCLee KSNg LCChua RCLeo YSHapuarachchi HCThein TLLee LKShi YfalseClinical outcome and genetic differences within a monophyletic Dengue virus type 2 population.The exact mechanisms of interplay between host and viral factors leading to severe dengue are yet to be fully understood. Even though previous studies have implicated specific genetic differences of Dengue virus (DENV) in clinical severity and virus attenuation, similar studies with large-scale, whole genome screening of monophyletic virus populations are limited. Therefore, in the present study, we compared 89 whole genomes of DENV-2 cosmopolitan clade III isolates obtained from patients diagnosed with dengue fever (DF, n = 58), dengue hemorrhagic fever (DHF, n = 30) and dengue shock syndrome (DSS, n = 1) in Singapore between July 2010 and January 2013, in order to determine the correlation of observed viral genetic differences with clinical outcomes. Our findings showed no significant di2015-01-01T00:00:00Z20152026-04-29T02:44:17.282Z2019-03-26T23:30:55ZS-EPMC43749452581165710.1371/journal.pone.0121696