{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iqbal K"],"funding":["NIEHS NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["59"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4376074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["<h4>Background</h4>Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the germ cells of the unexposed G2 grandchild.<h4>Results</h4>Here, we treat gestating female mice with vinclozolin, bisphenol A, or di-(2-ethylhexyl)phthalate during the time when global de novo DNA methylation and imprint establishment occurs in the germ cells of the G1 male fetus. We map genome-wide features in purified G1 and G2 prospermatogonia, in order to detect immediate and persistent epi"],"journal":["Genome biology"],"pubmed_title":["Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming."],"pmcid":["PMC4376074"],"funding_grant_id":["R01ES015185","R01GM064378","P30 CA033572","R01 ES015185","R01 GM064378"],"pubmed_authors":["Warden C","Li AX","Bai AY","Singh P","Szabo PE","Iqbal K","Pfeifer GP","Tran DA","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming.","description":"<h4>Background</h4>Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the germ cells of the unexposed G2 grandchild.<h4>Results</h4>Here, we treat gestating female mice with vinclozolin, bisphenol A, or di-(2-ethylhexyl)phthalate during the time when global de novo DNA methylation and imprint establishment occurs in the germ cells of the G1 male fetus. We map genome-wide features in purified G1 and G2 prospermatogonia, in order to detect immediate and persistent epi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2026-06-14T05:26:11.857Z","creation":"2026-06-14T03:09:26.882Z"},"accession":"S-EPMC4376074","cross_references":{"pubmed":["25853433"],"doi":["10.1186/s13059-015-0619-z"]}}