{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Langaee TY"],"funding":["NCATS NIH HHS","NIEHS NIH HHS","NIGMS NIH HHS"],"pagination":["239-45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4382440"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(5)"],"pubmed_abstract":["Background/objectives
The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of the GSTZ1 protein, so it is important to document variables that affect expression. Following up on a limited previous study, we tested the hypothesis that a coding single nucleotide polymorphism (SNP), the lysine (K) amino acid (E32>K) in GSTZ1 haplotypes linked to a promoter region SNP results in lower hepatic expression of GSTZ1.Materials and methods
The influence of K carrier and non-K carrier haplotypes on GSTZ1 expression was determined by analyzing 78 liver samples from in"],"journal":["Pharmacogenetics and genomics"],"pubmed_title":["The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression."],"pmcid":["PMC4382440"],"funding_grant_id":["ES07355","R01 GM081344","GM099871","R01 ES007355","GM081344","R01 GM099871","UL1 TR001427"],"pubmed_authors":["Langaee TY","Li W","Solayman MH","Stacpoole PW","McDonough CW","Zhong G","James MO","Hamadeh I"],"additional_accession":[]},"is_claimable":false,"name":"The influence of human GSTZ1 gene haplotype variations on GSTZ1 expression.","description":"Background/objectives
The zeta-1 family isoform of GST biotransforms the investigational drug dichloroacetate (DCA) and certain other halogenated carboxylic acids. Haplotype variability in GSTZ1 influences the kinetics and, possibly, the toxicity of DCA. DCA metabolism correlates with expression of the GSTZ1 protein, so it is important to document variables that affect expression. Following up on a limited previous study, we tested the hypothesis that a coding single nucleotide polymorphism (SNP), the lysine (K) amino acid (E32>K) in GSTZ1 haplotypes linked to a promoter region SNP results in lower hepatic expression of GSTZ1.Materials and methods
The influence of K carrier and non-K carrier haplotypes on GSTZ1 expression was determined by analyzing 78 liver samples from in","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2026-04-30T14:33:51.899Z","creation":"2026-04-07T16:04:47.861Z"},"accession":"S-EPMC4382440","cross_references":{"pubmed":["25738370"],"doi":["10.1097/FPC.0000000000000129","10.1097/fpc.0000000000000129"]}}