{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20"],"submitter":["Siqueira ER"],"pubmed_abstract":["<h4>Background</h4>Given the important contribution of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system to the generation of reactive oxygen species induced by hepatitis C virus (HCV), we investigated two single nucleotide polymorphisms (SNPs) in the putative regulatory region of the genes encoding NADPH oxidase 4 catalytic subunit (NOX4) and its regulatory subunit p22phox (CYBA) and their relation with metabolic and histological variables in patients with HCV.<h4>Methods</h4>One hundred seventy eight naïve HCV patients (49.3% male; 65% HCV genotype 1) with positive HCV RNA were genotyped using specific primers and fluorescent-labeled probes for SNPs rs3017887 in NOX4 and -675 T → A in CYBA.<h4>Results</h4>No association was found between the genotype frequencies of N"],"journal":["European journal of medical research"],"pagination":["45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4383049"],"repository":["biostudies-literature"],"pubmed_title":["Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C."],"pmcid":["PMC4383049"],"pubmed_authors":["Cavaleiro AM","Oliveira CP","Stefano JT","Silva Vasconcelos LR","Patente T","Pereira LB","Carmo RF","Carrilho FJ","Siqueira ER","Moreira Beltrao Pereira LM","Correa-Giannella ML"],"additional_accession":[]},"is_claimable":false,"name":"Association of a variant in the regulatory region of NADPH oxidase 4 gene and metabolic syndrome in patients with chronic hepatitis C.","description":"<h4>Background</h4>Given the important contribution of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system to the generation of reactive oxygen species induced by hepatitis C virus (HCV), we investigated two single nucleotide polymorphisms (SNPs) in the putative regulatory region of the genes encoding NADPH oxidase 4 catalytic subunit (NOX4) and its regulatory subunit p22phox (CYBA) and their relation with metabolic and histological variables in patients with HCV.<h4>Methods</h4>One hundred seventy eight naïve HCV patients (49.3% male; 65% HCV genotype 1) with positive HCV RNA were genotyped using specific primers and fluorescent-labeled probes for SNPs rs3017887 in NOX4 and -675 T → A in CYBA.<h4>Results</h4>No association was found between the genotype frequencies of N","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2025-04-26T17:15:30.161Z","creation":"2019-03-27T01:49:15Z"},"accession":"S-EPMC4383049","cross_references":{"pubmed":["25888935"],"doi":["10.1186/s40001-015-0136-2"]}}