{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bhandari P"],"funding":["NHLBI NIH HHS"],"pagination":["257-65"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4392818"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["114(2)"],"pubmed_abstract":["<h4>Rationale</h4>Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood.<h4>Objective</h4>We used germline mutants and cardiac-specific RNA interference to interrogate Parkin regulation of cardiomyocyte mitochondria and examine functional crosstalk between mitophagy and mitochondrial dynamics in Drosophila heart tubes.<h4>Methods and results</h4>Transcriptional profiling of Parkin knockout mouse hearts revealed compensatory upregulation of multiple relate"],"journal":["Circulation research"],"pubmed_title":["Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin."],"pmcid":["PMC4392818"],"funding_grant_id":["R01 HL059888","R21 HL107276","HL107276","HL59888"],"pubmed_authors":["Song M","Dorn GW","Chen Y","Burelle Y","Bhandari P"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.","description":"<h4>Rationale</h4>Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood.<h4>Objective</h4>We used germline mutants and cardiac-specific RNA interference to interrogate Parkin regulation of cardiomyocyte mitochondria and examine functional crosstalk between mitophagy and mitochondrial dynamics in Drosophila heart tubes.<h4>Methods and results</h4>Transcriptional profiling of Parkin knockout mouse hearts revealed compensatory upregulation of multiple relate","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jan","modification":"2025-04-18T19:17:43.268Z","creation":"2019-03-26T23:49:36Z"},"accession":"S-EPMC4392818","cross_references":{"pubmed":["24192653"],"doi":["10.1161/CIRCRESAHA.114.302734","10.1161/circresaha.114.302734"]}}