biostudies-literatureBhandari PNHLBI NIH HHS257-65https://www.ebi.ac.uk/biostudies/studies/S-EPMC4392818biostudies-literatureUnknown114(2)<h4>Rationale</h4>Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood.<h4>Objective</h4>We used germline mutants and cardiac-specific RNA interference to interrogate Parkin regulation of cardiomyocyte mitochondria and examine functional crosstalk between mitophagy and mitochondrial dynamics in Drosophila heart tubes.<h4>Methods and results</h4>Transcriptional profiling of Parkin knockout mouse hearts revealed compensatory upregulation of multiple relateCirculation researchMitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.PMC4392818R01 HL059888R21 HL107276HL107276HL59888Song MDorn GWChen YBurelle YBhandari PfalseMitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.<h4>Rationale</h4>Dysfunctional Parkin-mediated mitophagic culling of senescent or damaged mitochondria is a major pathological process underlying Parkinson disease and a potential genetic mechanism of cardiomyopathy. Despite epidemiological associations between Parkinson disease and heart failure, the role of Parkin and mitophagic quality control in maintaining normal cardiac homeostasis is poorly understood.<h4>Objective</h4>We used germline mutants and cardiac-specific RNA interference to interrogate Parkin regulation of cardiomyocyte mitochondria and examine functional crosstalk between mitophagy and mitochondrial dynamics in Drosophila heart tubes.<h4>Methods and results</h4>Transcriptional profiling of Parkin knockout mouse hearts revealed compensatory upregulation of multiple relate2014-01-01T00:00:00Z2014 Jan2025-04-18T19:17:43.268Z2019-03-26T23:49:36ZS-EPMC43928182419265310.1161/CIRCRESAHA.114.30273410.1161/circresaha.114.302734