{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(4)"],"submitter":["Lund K"],"pubmed_abstract":["<h4>Background</h4>Pancreatic adenocarcinoma is a lethal disease with 5-year survival of less than 5%. 5-fluorouracil (5-FU) is a principal first-line therapy, but treatment only extends survival modestly and is seldom curative. Drug resistance and disease recurrence is typical and there is a pressing need to overcome this. To investigate acquired 5-FU resistance in pancreatic adenocarcinoma, we established chemoresistant monoclonal cell lines from the Panc 03.27 cell line by long-term exposure to increasing doses of 5-FU.<h4>Results</h4>5-FU-resistant cell lines exhibited increased expression of markers associated with multidrug resistance explaining their reduced sensitivity to 5-FU. In addition, 5-FU-resistant cell lines showed alterations typical for an epithelial-to-mesenchymal transi"],"journal":["PloS one"],"pagination":["e0123684"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4393253"],"repository":["biostudies-literature"],"pubmed_title":["Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment."],"pmcid":["PMC4393253"],"pubmed_authors":["Dembinski JL","Solberg N","Krauss S","Urbanucci A","Mills IG","Lund K"],"additional_accession":[]},"is_claimable":false,"name":"Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment.","description":"<h4>Background</h4>Pancreatic adenocarcinoma is a lethal disease with 5-year survival of less than 5%. 5-fluorouracil (5-FU) is a principal first-line therapy, but treatment only extends survival modestly and is seldom curative. Drug resistance and disease recurrence is typical and there is a pressing need to overcome this. To investigate acquired 5-FU resistance in pancreatic adenocarcinoma, we established chemoresistant monoclonal cell lines from the Panc 03.27 cell line by long-term exposure to increasing doses of 5-FU.<h4>Results</h4>5-FU-resistant cell lines exhibited increased expression of markers associated with multidrug resistance explaining their reduced sensitivity to 5-FU. In addition, 5-FU-resistant cell lines showed alterations typical for an epithelial-to-mesenchymal transi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-04-30T03:26:51.702Z","creation":"2019-03-26T23:32:00Z"},"accession":"S-EPMC4393253","cross_references":{"pubmed":["25860483"],"doi":["10.1371/journal.pone.0123684"]}}