{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4"],"submitter":["Kelley M"],"funding":["American Cancer Society","NIBIB NIH HHS","NCRR NIH HHS","National Institutes of Health (NIH)","National Marfan Foundation (NMF)","NINDS NIH HHS","Human Frontier Science Program (HFSP)","Fondo Nacional de Desarrollo Científico y Tecnológico","NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["During development, biomechanical forces contour the body and provide shape to internal organs. Using genetic and molecular approaches in combination with a FRET-based tension sensor, we characterized a pulling force exerted by the elongating pharynx (foregut) on the anterior epidermis during C. elegans embryogenesis. Resistance of the epidermis to this force and to actomyosin-based circumferential constricting forces is mediated by FBN-1, a ZP domain protein related to vertebrate fibrillins. fbn-1 was required specifically within the epidermis and FBN-1 was expressed in epidermal cells and secreted to the apical surface as a putative component of the embryonic sheath. Tiling array studies indicated that fbn-1 mRNA processing requires the conserved alternative splicing factor MEC-8/RBPMS. "],"journal":["eLife"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4395870"],"repository":["biostudies-literature"],"pubmed_title":["FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis."],"pmcid":["PMC4395870"],"funding_grant_id":["NS073121","1131038","R01 GM108754","S10RR02557401","P40 OD010440","Long-Term Fellowship","GM108754","NS047715","EB006745","1K99NS089942-01","R01 NS064273","R01 GM066868","GM30997","RSG-12-149-01-DCC","R37 GM030997","K99 NS089942","P20 GM103432","R01 EB006745","R01 GM030997","R01 NS073121","GM066868","NS064273","R01 NS047715"],"pubmed_authors":["Fay DS","Kelley M","Heiman MG","Krieg M","Calixto A","Chalfie M","Yochem J","Kuzmanov A","Frand A","Meli V","Goodman MB","Shaham S"],"additional_accession":[]},"is_claimable":false,"name":"FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.","description":"During development, biomechanical forces contour the body and provide shape to internal organs. Using genetic and molecular approaches in combination with a FRET-based tension sensor, we characterized a pulling force exerted by the elongating pharynx (foregut) on the anterior epidermis during C. elegans embryogenesis. Resistance of the epidermis to this force and to actomyosin-based circumferential constricting forces is mediated by FBN-1, a ZP domain protein related to vertebrate fibrillins. fbn-1 was required specifically within the epidermis and FBN-1 was expressed in epidermal cells and secreted to the apical surface as a putative component of the embryonic sheath. Tiling array studies indicated that fbn-1 mRNA processing requires the conserved alternative splicing factor MEC-8/RBPMS. ","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Mar","modification":"2026-05-07T22:02:01.356Z","creation":"2025-06-01T00:10:00.833Z"},"accession":"S-EPMC4395870","cross_references":{"pubmed":["25798732"],"doi":["10.7554/eLife.06565"]}}