biostudies-literatureUnknown7(2)Wang CThoracic aortic aneurysm (TAA) is progressive fatal aortic pathological dilation. However, the underlying molecular mechanisms are still largely unknown. Evidences suggest that endothelial cells and renin-angiotensin system may participate in the pathogenesis of TAA. This study aimed to investigate whether angiotensin II type 2 receptor (AT2) positive cells are involved in TAA formation. The mRNA level of AT2 is dramatically elevated in TAA compared with in controls. CD4(+)AT2(+) cells increased in both aortic wall and circulation of TAA patients. The levels of IL-1β and IL-17B in CD4(+)AT2(+) cells were lower than those in CD4(+)AT2(-) cells. When compared with endothelial cells (ECs) cultured alone, CD4(+)AT2(+) cells showed an inhibitory effect on proliferation and MMP2 expression in ECAmerican journal of translational research232-41https://www.ebi.ac.uk/biostudies/studies/S-EPMC4399088biostudies-literatureIdentification and characterization of CD4(+)AT2(+) T lymphocyte population in human thoracic aortic aneurysm.PMC4399088Liu JLi JHu ZWang CHu XFeng YHuang RLian FZhai XXue SWang WGu JChen YWu TXie BfalseIdentification and characterization of CD4(+)AT2(+) T lymphocyte population in human thoracic aortic aneurysm.Thoracic aortic aneurysm (TAA) is progressive fatal aortic pathological dilation. However, the underlying molecular mechanisms are still largely unknown. Evidences suggest that endothelial cells and renin-angiotensin system may participate in the pathogenesis of TAA. This study aimed to investigate whether angiotensin II type 2 receptor (AT2) positive cells are involved in TAA formation. The mRNA level of AT2 is dramatically elevated in TAA compared with in controls. CD4(+)AT2(+) cells increased in both aortic wall and circulation of TAA patients. The levels of IL-1β and IL-17B in CD4(+)AT2(+) cells were lower than those in CD4(+)AT2(-) cells. When compared with endothelial cells (ECs) cultured alone, CD4(+)AT2(+) cells showed an inhibitory effect on proliferation and MMP2 expression in EC2015-01-01T00:00:00Z20152025-04-04T23:24:11.163Z2019-03-27T01:50:00ZS-EPMC439908825901193