{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jones MK"],"funding":["NIDCR NIH HHS","NIAID NIH HHS"],"pagination":["755-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4401463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["346(6210)"],"pubmed_abstract":["The cell tropism of human noroviruses and the development of an in vitro infection model remain elusive. Although susceptibility to individual human norovirus strains correlates with an individual's histo-blood group antigen (HBGA) profile, the biological basis of this restriction is unknown. We demonstrate that human and mouse noroviruses infected B cells in vitro and likely in vivo. Human norovirus infection of B cells required the presence of HBGA-expressing enteric bacteria. Furthermore, mouse norovirus replication was reduced in vivo when the intestinal microbiota was depleted by means of oral antibiotic administration. Thus, we have identified B cells as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development o"],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Enteric bacteria promote human and mouse norovirus infection of B cells."],"pmcid":["PMC4401463"],"funding_grant_id":["R01 DE019783","T90 DE021990","T32 AI007110","T90 DE021990-02","R21 AI103961","R01 AI080611"],"pubmed_authors":["Wobus CE","Iovine NM","Jones MK","Vinje J","Gonzalez-Hernandez MB","Tibbetts SA","Wallet SM","Graves CL","Grau KR","Keyes LR","Watanabe M","Karst SM","Zhu S"],"additional_accession":[]},"is_claimable":false,"name":"Enteric bacteria promote human and mouse norovirus infection of B cells.","description":"The cell tropism of human noroviruses and the development of an in vitro infection model remain elusive. Although susceptibility to individual human norovirus strains correlates with an individual's histo-blood group antigen (HBGA) profile, the biological basis of this restriction is unknown. We demonstrate that human and mouse noroviruses infected B cells in vitro and likely in vivo. Human norovirus infection of B cells required the presence of HBGA-expressing enteric bacteria. Furthermore, mouse norovirus replication was reduced in vivo when the intestinal microbiota was depleted by means of oral antibiotic administration. Thus, we have identified B cells as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development o","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2025-04-18T16:38:49.107Z","creation":"2019-03-27T01:50:05Z"},"accession":"S-EPMC4401463","cross_references":{"pubmed":["25378626"],"doi":["10.1126/science.1257147"]}}