biostudies-literatureAleksandrova KCancer Research UKMedical Research CouncilNational Institute for Health Research (NIHR)djv010https://www.ebi.ac.uk/biostudies/studies/S-EPMC4402364biostudies-literatureUnknown107(4)Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 659Journal of the National Cancer InstituteA prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.PMC4402364MC_UU_12015/1G1000143NF-SI-0512-10135NF-SI-0512-10114G040152716491MC_U106179471Palli DCross AJLu YBoeing HKaaks RSeveri GFedirko VRacine AFreisling HKhaw KTTrichopoulos DTrichopoulou ASieri SVollset SEUeland PMTjonneland AWeiderpass EBoutron-Ruault MCTell GSChirlaque MDMay AMLjuslinder IKuhn TLagiou PWareham NJMidttun OGunter MJRiboli EJakszyn PPalmqvist RJenab MOvervad KSanchez MJTumino RArdanaz EBueno-de-Mesquita BVineis PPanico SQuiros JRAleksandrova KKong SYDorronsoro MZuo HChuang SCPischon TJohansson MTravis RCfalseA prospective study of the immune system activation biomarker neopterin and colorectal cancer risk.Neopterin may be relevant for colorectal cancer (CRC) development, as a biomarker of cellular immune activity exerting pleiotropic effects on cellular ageing, oxidative stress, and inflammation. So far, the association between prediagnostic neopterin and colon and rectal cancer risk has not been evaluated in human populations. A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition cohort using data on plasma concentrations of total neopterin (T-N, sum of neopterin and 7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and 269 rectal) matched within risk sets to 830 control participants. A subsequent replication study used data from the Hordaland Health Study, where 173 CRC case patients have been diagnosed among 6592015-01-01T00:00:00Z2015 Apr2025-04-19T00:47:53.716Z2019-03-27T01:50:07ZS-EPMC44023642571316510.1093/jnci/djv010