{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["107(4)"],"submitter":["Ager EI"],"pubmed_abstract":["Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5-10 per group) were treated with an anti-MMP14 inhibitory antibody (DX-2400), IgG control, fractionated radiation therapy, or their combination. We assessed primary tumor growth, transforming growth factor β (TGFβ) and inducible nitric oxide synthase (iNOS) expression, macrophage phenotype, and vascular parameters. A linear mixed model with repeated observations, with Mann-Whitney or analysis of variance with Bonferroni post hoc adjustment, was used to determine statistical significance. All statistical tests were two-sided. DX-2400 inhibited tumor growth compared with IgG contro"],"journal":["Journal of the National Cancer Institute"],"pagination":["djv017"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4402365"],"repository":["biostudies-literature"],"pubmed_title":["Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy."],"pmcid":["PMC4402365"],"pubmed_authors":["Askoxylakis V","Devy L","Ager EI","Boucher Y","Kodack DP","Fukumura D","Jain RK","Goel S","Snuderl M","Kirkpatrick ND","Finkelstein DM","Dransfield DT","Huang Y","Kozin SV","Muzikansky A","Seano G"],"additional_accession":[]},"is_claimable":false,"name":"Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.","description":"Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5-10 per group) were treated with an anti-MMP14 inhibitory antibody (DX-2400), IgG control, fractionated radiation therapy, or their combination. We assessed primary tumor growth, transforming growth factor β (TGFβ) and inducible nitric oxide synthase (iNOS) expression, macrophage phenotype, and vascular parameters. A linear mixed model with repeated observations, with Mann-Whitney or analysis of variance with Bonferroni post hoc adjustment, was used to determine statistical significance. All statistical tests were two-sided. DX-2400 inhibited tumor growth compared with IgG contro","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2025-04-19T00:47:57.67Z","creation":"2019-03-27T01:50:07Z"},"accession":"S-EPMC4402365","cross_references":{"pubmed":["25710962"],"doi":["10.1093/jnci/djv017"]}}