biostudies-literatureUnknown107(4)Ager EIMatrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5-10 per group) were treated with an anti-MMP14 inhibitory antibody (DX-2400), IgG control, fractionated radiation therapy, or their combination. We assessed primary tumor growth, transforming growth factor β (TGFβ) and inducible nitric oxide synthase (iNOS) expression, macrophage phenotype, and vascular parameters. A linear mixed model with repeated observations, with Mann-Whitney or analysis of variance with Bonferroni post hoc adjustment, was used to determine statistical significance. All statistical tests were two-sided. DX-2400 inhibited tumor growth compared with IgG controJournal of the National Cancer Institutedjv017https://www.ebi.ac.uk/biostudies/studies/S-EPMC4402365biostudies-literatureBlockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.PMC4402365Askoxylakis VDevy LAger EIBoucher YKodack DPFukumura DJain RKGoel SSnuderl MKirkpatrick NDFinkelstein DMDransfield DTHuang YKozin SVMuzikansky ASeano GfalseBlockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5-10 per group) were treated with an anti-MMP14 inhibitory antibody (DX-2400), IgG control, fractionated radiation therapy, or their combination. We assessed primary tumor growth, transforming growth factor β (TGFβ) and inducible nitric oxide synthase (iNOS) expression, macrophage phenotype, and vascular parameters. A linear mixed model with repeated observations, with Mann-Whitney or analysis of variance with Bonferroni post hoc adjustment, was used to determine statistical significance. All statistical tests were two-sided. DX-2400 inhibited tumor growth compared with IgG contro2015-01-01T00:00:00Z2015 Apr2025-04-19T00:47:57.67Z2019-03-27T01:50:07ZS-EPMC44023652571096210.1093/jnci/djv017