biostudies-literatureUnknown8(2)Xia T<h4>Objective</h4>Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD.<h4>Methods</h4>We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software RevieInternational journal of clinical and experimental medicine2219-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC4402801biostudies-literatureAssociation of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heartdisease: a meta-analysis.PMC4402801Liu XLi GJin XDu CJKong XQXia TfalseAssociation of Leu125Val polymorphisms in the PECAM-1 gene with the risk of coronary heartdisease: a meta-analysis.<h4>Objective</h4>Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD.<h4>Methods</h4>We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software Revie2015-01-01T00:00:00Z20152025-04-20T01:14:33.276Z2024-11-08T09:15:45.927ZS-EPMC440280125932154