{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wegman MP"],"funding":["NCATS NIH HHS","NICHD NIH HHS","NIA NIH HHS","NHLBI NIH HHS"],"pagination":["162-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4403246"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Caloric restriction has consistently been shown to extend life span and ameliorate aging-related diseases. These effects may be due to diet-induced reactive oxygen species acting to up-regulate sirtuins and related protective pathways, which research suggests may be partially inhibited by dietary anti-oxidant supplementation. Because caloric restriction is not sustainable long term for most humans, we investigated an alternative dietary approach, intermittent fasting (IF), which is proposed to act on similar biological pathways. We hypothesized that a modified IF diet, where participants maintain overall energy balance by alternating between days of fasting (25% of normal caloric intake) and feasting (175% of normal), would increase expression of genes associated with aging and reduce oxid"],"journal":["Rejuvenation research"],"pubmed_title":["Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism."],"pmcid":["PMC4403246"],"funding_grant_id":["1 P30AG028740","UL1 TR000064","TL1 TR000066","P30 AG028740","T32 HD043730","T32 HL083810","UL1 TR001427"],"pubmed_authors":["Wegman MP","Williams TA","Lu X","Leeuwenburgh C","Hsu SI","Xu J","Guo MH","Anton SD","Goldberg LA","Brantly ML","Shankar MN","Bennion DM","Chrzanowski SM"],"additional_accession":[]},"is_claimable":false,"name":"Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism.","description":"Caloric restriction has consistently been shown to extend life span and ameliorate aging-related diseases. These effects may be due to diet-induced reactive oxygen species acting to up-regulate sirtuins and related protective pathways, which research suggests may be partially inhibited by dietary anti-oxidant supplementation. Because caloric restriction is not sustainable long term for most humans, we investigated an alternative dietary approach, intermittent fasting (IF), which is proposed to act on similar biological pathways. We hypothesized that a modified IF diet, where participants maintain overall energy balance by alternating between days of fasting (25% of normal caloric intake) and feasting (175% of normal), would increase expression of genes associated with aging and reduce oxid","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2026-04-13T21:09:22.664Z","creation":"2026-04-08T03:23:25.595Z"},"accession":"S-EPMC4403246","cross_references":{"pubmed":["25546413"],"doi":["10.1089/rej.2014.1624"]}}