{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bausch-Fluck D"],"funding":["Swiss National Science Foundation","European Research Council","NCI NIH HHS"],"pagination":["e0121314"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4404347"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(3)"],"pubmed_abstract":["Cell surface proteins are major targets of biomedical research due to their utility as cellular markers and their extracellular accessibility for pharmacological intervention. However, information about the cell surface protein repertoire (the surfaceome) of individual cells is only sparsely available. Here, we applied the Cell Surface Capture (CSC) technology to 41 human and 31 mouse cell types to generate a mass-spectrometry derived Cell Surface Protein Atlas (CSPA) providing cellular surfaceome snapshots at high resolution. The CSPA is presented in form of an easy-to-navigate interactive database, a downloadable data matrix and with tools for targeted surfaceome rediscovery (http://wlab.ethz.ch/cspa). The cellular surfaceome snapshots of different cell types, including cancer cells, res"],"journal":["PloS one"],"pubmed_title":["A mass spectrometric-derived cell surface protein atlas."],"pmcid":["PMC4404347"],"funding_grant_id":["U01CA152813","U01 CA152813","107679","233226"],"pubmed_authors":["Boheler KR","Bock T","Frei AP","Moest H","Schmidt A","Hartlova A","Cerciello F","Wollscheid B","Bourquin JP","Bausch-Fluck D","Yoon C","Mirkowska P","Aebersold R","Jacobs A","Schiess R","Zandstra P","Van Eyk JE","Omasits U","Gundry RL","Hofmann A"],"additional_accession":[]},"is_claimable":false,"name":"A mass spectrometric-derived cell surface protein atlas.","description":"Cell surface proteins are major targets of biomedical research due to their utility as cellular markers and their extracellular accessibility for pharmacological intervention. However, information about the cell surface protein repertoire (the surfaceome) of individual cells is only sparsely available. Here, we applied the Cell Surface Capture (CSC) technology to 41 human and 31 mouse cell types to generate a mass-spectrometry derived Cell Surface Protein Atlas (CSPA) providing cellular surfaceome snapshots at high resolution. The CSPA is presented in form of an easy-to-navigate interactive database, a downloadable data matrix and with tools for targeted surfaceome rediscovery (http://wlab.ethz.ch/cspa). The cellular surfaceome snapshots of different cell types, including cancer cells, res","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-04-14T09:36:29.234Z","creation":"2019-03-26T23:32:17Z"},"accession":"S-EPMC4404347","cross_references":{"pubmed":["25894527"],"doi":["10.1371/journal.pone.0121314"]}}