{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(4)"],"submitter":["Zhu X"],"pubmed_abstract":["MTO1, together with MSS1 and MTO2, is a gene involved in the pathway of encoding a mitochondria-specific RNA-modifying enzyme related to the post-transcriptional modification of mitochondrial tRNAs. We have previously shown that a mutation of the MTO2 or MSS1 gene can suppress the neomycin-sensitive phenotype of yeast carrying a mitochondrial 15S rRNA C1477G mutation. Here we report that a null mutation of MTO1 also can inhibit the aminoglycoside-sensitivity of yeast carrying mitochondrial 15S rRNA C1477G mutation. The C1477G mutation corresponds to the human 12S rRNA A1555G mutation. Yeast with an mtDNA C1477G mutation exhibits hypersensitivity to neomycin and displays mitochondrial function impairment beyond neomycin treatment. When the mto1 null mutation and mitochondrial C1477G mutatio"],"journal":["PloS one"],"pagination":["e0124200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4405582"],"repository":["biostudies-literature"],"pubmed_title":["MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutation."],"pmcid":["PMC4405582"],"pubmed_authors":["Zhou Q","Yan Q","He X","Zhu X","Wang W","Yu Z","Dai Y"],"additional_accession":[]},"is_claimable":false,"name":"MTO1 worked as a modifier in the aminoglycosides sensitivity of yeast carrying a mitochondrial 15S rRNA C1477G mutation.","description":"MTO1, together with MSS1 and MTO2, is a gene involved in the pathway of encoding a mitochondria-specific RNA-modifying enzyme related to the post-transcriptional modification of mitochondrial tRNAs. We have previously shown that a mutation of the MTO2 or MSS1 gene can suppress the neomycin-sensitive phenotype of yeast carrying a mitochondrial 15S rRNA C1477G mutation. Here we report that a null mutation of MTO1 also can inhibit the aminoglycoside-sensitivity of yeast carrying mitochondrial 15S rRNA C1477G mutation. The C1477G mutation corresponds to the human 12S rRNA A1555G mutation. Yeast with an mtDNA C1477G mutation exhibits hypersensitivity to neomycin and displays mitochondrial function impairment beyond neomycin treatment. When the mto1 null mutation and mitochondrial C1477G mutatio","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2026-05-03T04:34:42.348Z","creation":"2019-03-26T23:32:12Z"},"accession":"S-EPMC4405582","cross_references":{"pubmed":["25898254"],"doi":["10.1371/journal.pone.0124200"]}}