biostudies-literatureD'Alessio CNIDDK NIH HHS31-48https://www.ebi.ac.uk/biostudies/studies/S-EPMC4411176biostudies-literatureUnknown16(1)N-glycosylation in the endoplasmic reticulum (ER) consists of the transfer of a preassembled glycan conserved among species (Glc3Man9GlcNAc2) from a lipid donor to a consensus sequence within a nascent protein that is entering the ER. The protein-linked glycans are then processed by glycosidases and glycosyltransferases in the ER producing specific structures that serve as signalling molecules for the fate of the folding glycoprotein: to stay in the ER during the folding process, to be retrotranslocated to the cytosol for proteasomal degradation if irreversibly misfolded, or to pursue transit through the secretory pathway as a mature glycoprotein. In the ER, each glycan signalling structure is recognized by a specific lectin. A domain similar to that of the mannose 6-phosphate receptors (MCurrent protein & peptide scienceGlucosidase II and MRH-domain containing proteins in the secretory pathway.PMC4411176R01 DK042667R01DK042667D'Alessio CDahms NMfalseGlucosidase II and MRH-domain containing proteins in the secretory pathway.N-glycosylation in the endoplasmic reticulum (ER) consists of the transfer of a preassembled glycan conserved among species (Glc3Man9GlcNAc2) from a lipid donor to a consensus sequence within a nascent protein that is entering the ER. The protein-linked glycans are then processed by glycosidases and glycosyltransferases in the ER producing specific structures that serve as signalling molecules for the fate of the folding glycoprotein: to stay in the ER during the folding process, to be retrotranslocated to the cytosol for proteasomal degradation if irreversibly misfolded, or to pursue transit through the secretory pathway as a mature glycoprotein. In the ER, each glycan signalling structure is recognized by a specific lectin. A domain similar to that of the mannose 6-phosphate receptors (M2015-01-01T00:00:00Z20152025-04-04T11:05:12.293Z2019-06-06T14:18:32ZS-EPMC44111762569284610.2174/1389203716666150213160438