{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Leger H"],"funding":["Centre National de la Recherche Scientifique (CNRS)","Genopole Evry"],"pubmed_abstract":["The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for embryonic development. It mediates the base excision repair (BER) of G:T and G:U DNA mismatches arising from the deamination of 5-methyl cytosine (5-MeC) and cytosine, respectively. Recent studies have pointed at a role of TDG during the active demethylation of 5-MeC within CpG islands. TDG interacts with the histone acetylase CREB-binding protein (CBP) to activate CBP-dependent transcription. In addition, TDG also interacts with the retinoic acid receptor α (RARα), resulting in the activation of RARα target genes. Here we provide evidence for the existence of a functional ternary complex containing TDG, CBP and activated RARα. Using global transcriptome profiling, we uncover a coupling of de novo methyla"],"journal":["Genomics, proteomics & bioinformatics"],"pagination":["8-18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4411359"],"repository":["biostudies-literature"],"pubmed_title":["A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes."],"pmcid":["PMC4411359"],"pubmed_authors":["Smet-Nocca C","Benecke AG","Morley-Fletcher S","Eilebrecht S","Leger H","Attmane-Elakeb A"],"additional_accession":[]},"is_claimable":false,"name":"A TDG/CBP/RARα ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes.","description":"The thymine DNA glycosylase (TDG) is a multifunctional enzyme, which is essential for embryonic development. It mediates the base excision repair (BER) of G:T and G:U DNA mismatches arising from the deamination of 5-methyl cytosine (5-MeC) and cytosine, respectively. Recent studies have pointed at a role of TDG during the active demethylation of 5-MeC within CpG islands. TDG interacts with the histone acetylase CREB-binding protein (CBP) to activate CBP-dependent transcription. In addition, TDG also interacts with the retinoic acid receptor α (RARα), resulting in the activation of RARα target genes. Here we provide evidence for the existence of a functional ternary complex containing TDG, CBP and activated RARα. Using global transcriptome profiling, we uncover a coupling of de novo methyla","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Feb","modification":"2025-04-18T17:30:53.242Z","creation":"2019-03-27T01:50:36Z"},"accession":"S-EPMC4411359","cross_references":{"pubmed":["24394593"],"doi":["10.1016/j.gpb.2013.11.001"]}}