{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aylward EH"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NINDS NIH HHS"],"pagination":["477-89"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4412155"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(4)"],"pubmed_abstract":["Background
Neuroimaging studies suggest that volumetric MRI measures of specific brain structures may serve as excellent biomarkers in future clinical trials of Huntington disease (HD).Objective
Demonstration of the clinical significance of these measures is an important step in determining their appropriateness as potential outcome measures.Methods
Measures of gray- and white-matter lobular volumes and subcortical volumes (caudate, putamen, globus pallidus, thalamus, nucleus accumbens, hippocampus) were obtained from MRI scans of 516 individuals who tested positive for the HD gene expansion, but were not yet exhibiting signs or symptoms severe enough to warrant diagnosis (\"pre-HD\"). MRI volumes (corrected for intracranial volume) were correlated with cognitive, mot"],"journal":["Journal of Huntington's disease"],"pubmed_title":["Regional atrophy associated with cognitive and motor function in prodromal Huntington disease."],"pmcid":["PMC4412155"],"funding_grant_id":["U01 NS082083","U01 NS082085","2 UL1 TR000442-06","U01 NS082086","R01 NS054893","UL1 TR000442","PD30 HD02274","1U01NS082085","1U01NS082086","5R01NS040068","P30 HD002274","1U01NS082083","5R01NS054893","R01 NS040068"],"pubmed_authors":["Martin W","Sran S","Maxwell B","Burrows M","Suter G","Chesire A","Craufurd D","Ahmed A","Mourany L","Trautmann S","Paulsen JS","Perlmutter J","Coleman A","Pallai J","Rosas D","Rae D","Nopoulos PC","Wheelock V","D'Alessandro M","Wojcieszek J","Wesson M","Suchowersky O","Long JD","Gunn D","Clemente B","Rosser A","Preston J","Jankovic J","Bek J","Wood-Siverio C","Lee J","Barth K","Howard E","Marder K","Cross S","Yoritomo N","Ross CA","Guzman NV","Wieler M","Mason S","Sussmuth S","Nance M","Wodarski M","Price K","Perlman S","Hickey C","Fan M","Chiu E","Varvaris M","Orth M","PREDICT-HD Investigators and Coordinators of the Huntington Study Group","Miedzybrodzka Z","Decolongon J","Farias S","Barker RA","Sha S","Law A","Chua P","Sheinberg A","Panegyres P","Ondo W","Kumar R","Wasserman P","Antonopoulos S","Satris G","Westervelt HK","Kjer L","Goh A","Reece C","Quaid K","Hunt S","Griffith J","Harrington DL","McCusker E","Mazzoni P","Loy C","Loi S","Dubinsky R","Jones R","Nickels B","Komiti A","Ryan P","Epping EA","Bura A","Geschwind MD","De Yebenes JG","Factor SA","Aylward EH","Warner T","Raymond L","King P","Mills JA","Barton S","Erickson D","Samii A","Macaraeg A","Mallonee WM","Tedesco M","Marshall F","Guttman M","Martin A","Smith S","Eschenbach C","Schwenk D","Liu D"],"additional_accession":[]},"is_claimable":false,"name":"Regional atrophy associated with cognitive and motor function in prodromal Huntington disease.","description":"Background
Neuroimaging studies suggest that volumetric MRI measures of specific brain structures may serve as excellent biomarkers in future clinical trials of Huntington disease (HD).Objective
Demonstration of the clinical significance of these measures is an important step in determining their appropriateness as potential outcome measures.Methods
Measures of gray- and white-matter lobular volumes and subcortical volumes (caudate, putamen, globus pallidus, thalamus, nucleus accumbens, hippocampus) were obtained from MRI scans of 516 individuals who tested positive for the HD gene expansion, but were not yet exhibiting signs or symptoms severe enough to warrant diagnosis (\"pre-HD\"). MRI volumes (corrected for intracranial volume) were correlated with cognitive, mot","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013","modification":"2025-04-04T23:24:03.588Z","creation":"2019-03-27T01:50:38Z"},"accession":"S-EPMC4412155","cross_references":{"pubmed":["25062732"],"doi":["10.3233/JHD-130076","10.3233/jhd-130076"]}}