{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["112(16)"],"submitter":["Yang Z"],"pubmed_abstract":["Starved animals often exhibit elevated locomotion, which has been speculated to partly resemble foraging behavior and facilitate food acquisition and energy intake. Despite its importance, the neural mechanism underlying this behavior remains unknown in any species. In this study we confirmed and extended previous findings that starvation induced locomotor activity in adult fruit flies Drosophila melanogaster. We also showed that starvation-induced hyperactivity was directed toward the localization and acquisition of food sources, because it could be suppressed upon the detection of food cues via both central nutrient-sensing and peripheral sweet-sensing mechanisms, via induction of food ingestion. We further found that octopamine, the insect counterpart of vertebrate norepinephrine, as we"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pagination":["5219-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4413307"],"repository":["biostudies-literature"],"pubmed_title":["Octopamine mediates starvation-induced hyperactivity in adult Drosophila."],"pmcid":["PMC4413307"],"pubmed_authors":["Zhang V","Yang Z","Tian Y","Qi W","Yu Y","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Octopamine mediates starvation-induced hyperactivity in adult Drosophila.","description":"Starved animals often exhibit elevated locomotion, which has been speculated to partly resemble foraging behavior and facilitate food acquisition and energy intake. Despite its importance, the neural mechanism underlying this behavior remains unknown in any species. In this study we confirmed and extended previous findings that starvation induced locomotor activity in adult fruit flies Drosophila melanogaster. We also showed that starvation-induced hyperactivity was directed toward the localization and acquisition of food sources, because it could be suppressed upon the detection of food cues via both central nutrient-sensing and peripheral sweet-sensing mechanisms, via induction of food ingestion. We further found that octopamine, the insect counterpart of vertebrate norepinephrine, as we","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2025-06-01T00:07:28.604Z","creation":"2025-06-01T00:07:28.604Z"},"accession":"S-EPMC4413307","cross_references":{"pubmed":["25848004"],"doi":["10.1073/pnas.1417838112"]}}