biostudies-literatureUnknown36(5)Villarejo ASnail2 is a zinc finger transcription factor involved in driving epithelial to mesenchymal transitions. Snail2 null mice are viable, but display defects in melanogenesis, gametogenesis and hematopoiesis, and are markedly radiosensitive. Here, using mouse genetics, we have studied the contributions of Snail2 to epidermal homeostasis and skin carcinogenesis. Snail2 (-/-) mice presented a defective epidermal terminal differentiation and, unexpectedly, an increase in number, size and malignancy of tumor lesions when subjected to the two-stage mouse skin chemical carcinogenesis protocol, compared with controls. Additionally, tumor lesions from Snail2 (-/-) mice presented a high inflammatory component with an elevated percentage of myeloid precursors in tumor lesions that was further increased iCarcinogenesis585-97https://www.ebi.ac.uk/biostudies/studies/S-EPMC4417341biostudies-literatureLoss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.PMC4417341Villarejo AMoreno-Bueno GPortillo FCales CSantos VMolina-Ortiz PPeinado HMorales SGridley TPerez-Moreno MAMontenegro YCano AfalseLoss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.Snail2 is a zinc finger transcription factor involved in driving epithelial to mesenchymal transitions. Snail2 null mice are viable, but display defects in melanogenesis, gametogenesis and hematopoiesis, and are markedly radiosensitive. Here, using mouse genetics, we have studied the contributions of Snail2 to epidermal homeostasis and skin carcinogenesis. Snail2 (-/-) mice presented a defective epidermal terminal differentiation and, unexpectedly, an increase in number, size and malignancy of tumor lesions when subjected to the two-stage mouse skin chemical carcinogenesis protocol, compared with controls. Additionally, tumor lesions from Snail2 (-/-) mice presented a high inflammatory component with an elevated percentage of myeloid precursors in tumor lesions that was further increased i2015-01-01T00:00:00Z2015 May2025-04-26T08:00:06.482Z2019-03-27T01:50:53ZS-EPMC44173412578437510.1093/carcin/bgv021