{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yao S"],"funding":["Tianjin Municipal Science and Technology Commission"],"pagination":["317403"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4420799"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2015"],"pubmed_abstract":["In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy."],"journal":["BioMed research international"],"pubmed_title":["Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8."],"pmcid":["PMC4420799"],"funding_grant_id":["2011J5200025","2010B031600054","81371584","320675013203","2013B021800264","81201116","30970856","[2010]609","11ZCGHHZ00800","1563000312"],"pubmed_authors":["Nie D","Tang C","Sun T","Yao S","Hu K","Yao B","Jiang S","Tang G","Gao S"],"additional_accession":[]},"is_claimable":false,"name":"Molecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.","description":"In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015","modification":"2025-04-05T15:29:48.589Z","creation":"2019-03-27T01:51:03Z"},"accession":"S-EPMC4420799","cross_references":{"pubmed":["25977920"],"doi":["10.1155/2015/317403"]}}