biostudies-literatureYao STianjin Municipal Science and Technology Commission317403https://www.ebi.ac.uk/biostudies/studies/S-EPMC4420799biostudies-literatureUnknown2015In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.BioMed research internationalMolecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.PMC44207992011J52000252010B031600054813715843206750132032013B0218002648120111630970856[2010]60911ZCGHHZ008001563000312Nie DTang CSun TYao SHu KYao BJiang STang GGao SfalseMolecular PET Imaging of Cyclophosphamide Induced Apoptosis with 18F-ML-8.In this paper, a novel small-molecular apoptotic PET imaging probe, (18)F-ML-8 with a malonate motif structure, is presented and discussed. After study, the small tracer that belongs to a member of ApoSense family is proved to be capable of imaging merely apoptotic regions in the CTX treated tumor-bearing mice. The experimental result is further confirmed by in vitro cell binding assays and TUNEL staining assay. As a result, (18)F-ML-8 could be used for noninvasive visualization of apoptosis induced by antitumor chemotherapy.2015-01-01T00:00:00Z20152025-04-05T15:29:48.589Z2019-03-27T01:51:03ZS-EPMC44207992597792010.1155/2015/317403