{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(6)"],"submitter":["Patel E"],"funding":["Biotechnology and Biological Sciences Research Council"],"pubmed_abstract":["Despite recent improvements to in situ proteolysis strategies, a higher efficiency is still needed to increase both the number of peptides detected and the associated ion intensity, leading to a complete and reliable set of biomarkers for diagnostic or prognostic purposes. In the study presented here, an extract of a systematic study is illustrated investigating a range of surfactants assisting trypsin proteolytic activity. Method development was trialled on fingermarks; this specimen results from a transfer of sweat from an individual's fingertip to a surface upon contact. As sweat carries a plethora of biomolecules, including peptides and proteins, fingermarks are, potentially, a very valuable specimen for non-invasive prognostic or diagnostic screening. A recent study has demonstrated t"],"journal":["Journal of the American Society for Mass Spectrometry"],"pagination":["862-72"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4422860"],"repository":["biostudies-literature"],"pubmed_title":["Alternative surfactants for improved efficiency of in situ tryptic proteolysis of fingermarks."],"pmcid":["PMC4422860"],"pubmed_authors":["Francese S","Patel E","Marshall N","West A","Marshall PS","Clench MR"],"additional_accession":[]},"is_claimable":false,"name":"Alternative surfactants for improved efficiency of in situ tryptic proteolysis of fingermarks.","description":"Despite recent improvements to in situ proteolysis strategies, a higher efficiency is still needed to increase both the number of peptides detected and the associated ion intensity, leading to a complete and reliable set of biomarkers for diagnostic or prognostic purposes. In the study presented here, an extract of a systematic study is illustrated investigating a range of surfactants assisting trypsin proteolytic activity. Method development was trialled on fingermarks; this specimen results from a transfer of sweat from an individual's fingertip to a surface upon contact. As sweat carries a plethora of biomolecules, including peptides and proteins, fingermarks are, potentially, a very valuable specimen for non-invasive prognostic or diagnostic screening. A recent study has demonstrated t","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jun","modification":"2025-04-22T10:28:11.826Z","creation":"2019-03-27T01:51:08Z"},"accession":"S-EPMC4422860","cross_references":{"pubmed":["25916599"],"doi":["10.1007/s13361-015-1140-z"]}}