{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Yu LX"],"pubmed_abstract":["<h4>Background</h4>Streptococcus mutans (S. mutans) is the primary etiological agent of dental caries. Sortase is a transpeptidase that anchors several surface proteins to the S. mutans cell wall and has been shown to play a major role in cariogenicity. The purpose of this study was to explore the genetic polymorphisms of the sortase gene (srtA) and the social-behavioural factors associated with dental caries in children with S. mutans.<h4>Methods</h4>In this case-control study, 121 S. mutans strains were separately selected from caries-free children and high-severity caries children for sequencing of the srtA gene. Social and behavioural data were collected by self-administered questionnaires. Genomic DNA was extracted from S. mutans strains and amplified by PCR to obtain the srtA gene. T"],"journal":["BMC oral health"],"pagination":["54"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4423529"],"repository":["biostudies-literature"],"pubmed_title":["Genetic polymorphisms of the sortase A gene and social-behavioural factors associated with caries in children: a case-control study."],"pmcid":["PMC4423529"],"pubmed_authors":["Lin HC","Zhi QH","Tao Y","Yu LX","Qiu RM","Zhou Y"],"additional_accession":[]},"is_claimable":false,"name":"Genetic polymorphisms of the sortase A gene and social-behavioural factors associated with caries in children: a case-control study.","description":"<h4>Background</h4>Streptococcus mutans (S. mutans) is the primary etiological agent of dental caries. Sortase is a transpeptidase that anchors several surface proteins to the S. mutans cell wall and has been shown to play a major role in cariogenicity. The purpose of this study was to explore the genetic polymorphisms of the sortase gene (srtA) and the social-behavioural factors associated with dental caries in children with S. mutans.<h4>Methods</h4>In this case-control study, 121 S. mutans strains were separately selected from caries-free children and high-severity caries children for sequencing of the srtA gene. Social and behavioural data were collected by self-administered questionnaires. Genomic DNA was extracted from S. mutans strains and amplified by PCR to obtain the srtA gene. T","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-04-25T23:53:33.069Z","creation":"2019-03-27T01:51:11Z"},"accession":"S-EPMC4423529","cross_references":{"pubmed":["25934314"],"doi":["10.1186/s12903-015-0039-1"]}}