biostudies-literatureUnknown15Yu LX<h4>Background</h4>Streptococcus mutans (S. mutans) is the primary etiological agent of dental caries. Sortase is a transpeptidase that anchors several surface proteins to the S. mutans cell wall and has been shown to play a major role in cariogenicity. The purpose of this study was to explore the genetic polymorphisms of the sortase gene (srtA) and the social-behavioural factors associated with dental caries in children with S. mutans.<h4>Methods</h4>In this case-control study, 121 S. mutans strains were separately selected from caries-free children and high-severity caries children for sequencing of the srtA gene. Social and behavioural data were collected by self-administered questionnaires. Genomic DNA was extracted from S. mutans strains and amplified by PCR to obtain the srtA gene. TBMC oral health54https://www.ebi.ac.uk/biostudies/studies/S-EPMC4423529biostudies-literatureGenetic polymorphisms of the sortase A gene and social-behavioural factors associated with caries in children: a case-control study.PMC4423529Lin HCZhi QHTao YYu LXQiu RMZhou YfalseGenetic polymorphisms of the sortase A gene and social-behavioural factors associated with caries in children: a case-control study.<h4>Background</h4>Streptococcus mutans (S. mutans) is the primary etiological agent of dental caries. Sortase is a transpeptidase that anchors several surface proteins to the S. mutans cell wall and has been shown to play a major role in cariogenicity. The purpose of this study was to explore the genetic polymorphisms of the sortase gene (srtA) and the social-behavioural factors associated with dental caries in children with S. mutans.<h4>Methods</h4>In this case-control study, 121 S. mutans strains were separately selected from caries-free children and high-severity caries children for sequencing of the srtA gene. Social and behavioural data were collected by self-administered questionnaires. Genomic DNA was extracted from S. mutans strains and amplified by PCR to obtain the srtA gene. T2015-01-01T00:00:00Z2015 May2025-04-25T23:53:33.069Z2019-03-27T01:51:11ZS-EPMC44235292593431410.1186/s12903-015-0039-1