{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Maiolino S"],"pubmed_abstract":["<h4>Background</h4>Novel polymeric nanoparticles (NPs) specifically designed for delivering chemotherapeutics in the body and aimed at improving treatment activity and selectivity, cover a very relevant area in the field of nanomedicine. Here, we describe how to build a polymer shell of Hyaluronan (HA) and Polyethyleneimine (PEI) on biodegradable NPs of poly(lactic-co-glycolic) acid (PLGA) through electrostatic interactions and to achieve NPs with unique features of sustained delivery of a docetaxel (DTX) drug cargo as well as improved intracellular uptake.<h4>Results</h4>A stable PEI or HA/PEI shell could be obtained by careful selection of layering conditions. NPs with exquisite stability in salt and protein-rich media, with size and surface charge matching biological requirements for in"],"journal":["Journal of nanobiotechnology"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4424546"],"repository":["biostudies-literature"],"pubmed_title":["Biodegradable nanoparticles sequentially decorated with Polyethyleneimine and Hyaluronan for the targeted delivery of docetaxel to airway cancer cells."],"pmcid":["PMC4424546"],"pubmed_authors":["Maiolino S","Russo G","Quaglia F","Ungaro F","Pagliara V","Conte C","Russo A"],"additional_accession":[]},"is_claimable":false,"name":"Biodegradable nanoparticles sequentially decorated with Polyethyleneimine and Hyaluronan for the targeted delivery of docetaxel to airway cancer cells.","description":"<h4>Background</h4>Novel polymeric nanoparticles (NPs) specifically designed for delivering chemotherapeutics in the body and aimed at improving treatment activity and selectivity, cover a very relevant area in the field of nanomedicine. Here, we describe how to build a polymer shell of Hyaluronan (HA) and Polyethyleneimine (PEI) on biodegradable NPs of poly(lactic-co-glycolic) acid (PLGA) through electrostatic interactions and to achieve NPs with unique features of sustained delivery of a docetaxel (DTX) drug cargo as well as improved intracellular uptake.<h4>Results</h4>A stable PEI or HA/PEI shell could be obtained by careful selection of layering conditions. NPs with exquisite stability in salt and protein-rich media, with size and surface charge matching biological requirements for in","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Apr","modification":"2025-06-01T01:00:56.663Z","creation":"2025-06-01T01:00:56.663Z"},"accession":"S-EPMC4424546","cross_references":{"pubmed":["25888948"],"doi":["10.1186/s12951-015-0088-2"]}}